| Comparison of the effects of exercise and isoproterenol on the antegrade refractory period of the accessory pathway in patients with Wolff-Parkinson-White syndrome. | |
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MedLine Citation:
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PMID: 8139088 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of exercise and isoproterenol infusion on the antegrade effective refractory period of the accessory pathway (ERP-AP) were compared in 10 patients with Wolff-Parkinson-White (WPW) syndrome. During an electrophysiologic study, the ERP-AP (paced cycle length: 400 msec) was measured before and during isoproterenol infusion at a rate of 1 microgram/min. On the next day, a symptom-limited ergometer exercise test was performed and the ERP-AP (paced cycle length: 400 msec) was measured before and during the test using an indwelling atrial electrode catheter. Isoproterenol infusion and the exercise test increased the heart rate from 84 +/- 24 to 122 +/- 17 beats/min and from 85 +/- 25 to 128 +/- 25 beats/min, respectively (p = NS isoproterenol versus exercise). The ERP-AP was shortened from 268 +/- 34 to 230 +/- 19 msec with isoproterenol infusion (p < 0.001) and from 273 +/- 42 to 237 +/- 31 msec with the exercise test (p < 0.001). There was no significant difference between the effects of isoproterenol and exercise. The percent change in the ERP-AP with exercise (Y) was significantly correlated to that with isoproterenol infusion (X) (Y = -3.04 + 0.70X, r = 0.92, p < 0.001). In conclusion, isoproterenol infusion at the present dose shortens the ERP-AP to the same degree as exercise, and thus is useful for predicting the exercise-induced shortening of the ERP of the accessory pathway in patients with WPW syndrome. |
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Authors:
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H Yamabe; K Okumura; H Yasue |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Japanese circulation journal Volume: 58 ISSN: 0047-1828 ISO Abbreviation: Jpn. Circ. J. Publication Date: 1994 Jan |
Date Detail:
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Created Date: 1994-04-26 Completed Date: 1994-04-26 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7806868 Medline TA: Jpn Circ J Country: JAPAN |
Other Details:
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Languages: eng Pagination: 22-8 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Kumamoto University Medical School, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Exercise Test Female Heart Conduction System / drug effects, physiopathology* Humans Infusions, Parenteral Isoproterenol / administration & dosage, pharmacology* Male Middle Aged Physical Exertion* Refractory Period, Electrophysiological / drug effects, physiology* Wolff-Parkinson-White Syndrome / physiopathology* |
| Chemical | |
Reg. No./Substance:
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7683-59-2/Isoproterenol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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