| Comparison of the effects of dobutamine and isoproterenol in ischemic hearts by phosphorus-31 nuclear magnetic resonance spectroscopy. | |
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MedLine Citation:
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PMID: 8022049 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We compared the effects of 2 inotropic agents, dobutamine and isoproterenol on regional coronary blood flow, contractile function, hemodynamics and levels of phosphate compounds in the acutely ischemic canine heart. Dogs were instrumented to determine regional coronary blood flow (non-radioactive microsphere method), contractile function (sonomicrometry), and hemodynamics. Myocardial phosphate compounds were measured simultaneously by the phosphate-31 (31P) magnetic resonance spectroscopic technique. Both drugs augmented the global performance of the heart, but produced no significant improvement in regional contractile function in the ischemic region. Isoproterenol significantly increased the ratio of inorganic phosphate to phosphocreatine in the ischemic region, as compared to dobutamine. However, no significant differences were seen in myocardial lactate consumption with inotropic stimulation between the 2 groups. 31P magnetic resonance spectroscopy could be used to differentiate between the effects of dobutamine and isoproterenol on energy metabolism in ischemic myocardium despite the lack of significant differences in regional function and myocardial lactate consumption. The significant tachycardia without an augmentation of systemic blood pressure induced by isoproterenol may account for this unfavorable effect on myocardial energy metabolism. |
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Authors:
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S Yanagi; K Takeuchi; T Takeda; M Ishikawa; I Miura |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Japanese circulation journal Volume: 58 ISSN: 0047-1828 ISO Abbreviation: Jpn. Circ. J. Publication Date: 1994 May |
Date Detail:
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Created Date: 1994-08-03 Completed Date: 1994-08-03 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7806868 Medline TA: Jpn Circ J Country: JAPAN |
Other Details:
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Languages: eng Pagination: 338-50 Citation Subset: IM |
Affiliation:
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First Department of Internal Medicine, Osaka City University Medical School, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Coronary Circulation / drug effects Dobutamine / pharmacology* Dogs Female Hemodynamics / drug effects Isoproterenol / pharmacology* Lactates / metabolism Lactic Acid Magnetic Resonance Spectroscopy Male Myocardial Contraction / drug effects Myocardial Ischemia / metabolism*, physiopathology Myocardium / metabolism* Phosphates / metabolism Stimulation, Chemical |
| Chemical | |
Reg. No./Substance:
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0/Lactates; 0/Phosphates; 34368-04-2/Dobutamine; 50-21-5/Lactic Acid; 7683-59-2/Isoproterenol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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