Document Detail

Comparison of the effects of diets rich in stearic acid versus myristic acid and lauric acid on platelet fatty acids and excretion of thromboxane A2 and PGI2 metabolites in healthy young men.
MedLine Citation:
PMID:  8487669     Owner:  NLM     Status:  MEDLINE    
The present study compared the effects of diets rich in stearic acid (C18:0) versus one high in lauric and myristic acid (C12:0, C14:0) on platelet phospholipid fatty acid levels and concentrations of urinary thromboxane B2 (TXB2) and 6-keto-PGF1 alpha, which are stable metabolites of thromboxane A2 (TXA2) and PGI2 and indicators of cardiovascular hemostasis. A diet high in dairy butter (B) was the source of C12:0 and C14:0; C18:0 was provided by diets high in cocoa butter (CB), milk chocolate (CHOC) or CB+B in a 4:1 ratio (MIX). A randomized, crossover double-blind experimental design was used. Experimental subjects (n = 15) consumed each diet for 26 days, with a 1-month washout period between each experimental period. Urine and blood were collected from each subject at the beginning and end of each dietary period. Urinary TXB2 and 6-keto-PGF1 alpha were analyzed by radioimmunoassay (RIA). There were no effects of diet on the 24-hour excretion of either metabolite or on the ratio of 6-keto-PGF1 alpha/TXB2, even though there were significant changes in the eicosanoid precursor, arachidonic acid (C20:4n-6), in platelet phospholipids. C20:4n-6 levels increased (44.8% +/- 1.0% to 47.1% +/- 1.3%; P < .05) in the phosphatidylethanolamine phospholipid subclass in subjects on the B diet and decreased in the phosphatidylcholine subclass on the CB diet (16.5% +/- 1.0% to 14.2% +/- 1.1%; P < .05) compared with baseline values.(ABSTRACT TRUNCATED AT 250 WORDS)
V A Mustad; P M Kris-Etherton; J Derr; C C Reddy; T A Pearson
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  42     ISSN:  0026-0495     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-06-04     Completed Date:  1993-06-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  463-9     Citation Subset:  IM    
Graduate Program in Nutrition, Pennsylvania State University, University Park 16802.
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MeSH Terms
6-Ketoprostaglandin F1 alpha / urine
Blood Platelets / drug effects,  metabolism*
Dietary Fats / administration & dosage,  pharmacology*
Double-Blind Method
Epoprostenol / urine*
Fatty Acids / administration & dosage,  blood*,  pharmacology
Infant, Newborn
Lauric Acids / administration & dosage,  pharmacology
Myristic Acid
Myristic Acids / administration & dosage,  pharmacology
Phosphatidylcholines / blood
Phosphatidylethanolamines / blood
Stearic Acids / administration & dosage,  pharmacology
Thromboxane A2 / urine*
Thromboxane B2 / urine
Reg. No./Substance:
0/Dietary Fats; 0/Fatty Acids; 0/Lauric Acids; 0/Myristic Acids; 0/Phosphatidylcholines; 0/Phosphatidylethanolamines; 0/Stearic Acids; 143-07-7/lauric acid; 35121-78-9/Epoprostenol; 54397-85-2/Thromboxane B2; 544-63-8/Myristic Acid; 57-11-4/stearic acid; 57576-52-0/Thromboxane A2; 58962-34-8/6-Ketoprostaglandin F1 alpha; 8029-34-3/Butter

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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