Document Detail

Comparison of the effects of clonidine and hydroxyzine on haemodynamic and catecholamine reactions to microlaryngoscopy.
MedLine Citation:
PMID:  11270028     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVE: This study compares the effect of oral clonidine vs. hydroxyzine on the haemodynamic and catecholamine responses to microlaryngoscopy. METHODS: Thirty-five ASA II-III patients were included in this double-blind randomized trial. The patients received either hydroxyzine 1 mg kg-1 (n = 18) or clonidine 3 micrograms kg-1 (n = 17) for their oral premedication 100 min before an intravenous induction of anaesthesia using propofol (2-3 mg kg-1) and fentanyl (2 micrograms kg-1). Arterial pressure and heart rate were measured before premedication, and throughout the procedure and recovery. Plasma catecholamine levels were determined before premedication, after induction, and 1.5, 30 and 120 min after laryngoscopy. RESULTS: Mean arterial pressure was significantly lower after clonidine, whereas there was no difference in heart rate and plasma catecholamine levels between the two groups. CONCLUSIONS: Clonidine for premedication significantly decreased mean arterial pressure during microlaryngoscopy and the following recovery phase but did not modify the overall haemodynamic response to the suspension microlaryngoscopic nociceptive stimulus.
M Boussofara; D Bracco; P Ravussin
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  European journal of anaesthesiology     Volume:  18     ISSN:  0265-0215     ISO Abbreviation:  Eur J Anaesthesiol     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-03-28     Completed Date:  2001-05-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8411711     Medline TA:  Eur J Anaesthesiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  75-8     Citation Subset:  IM    
Institute Salah Azaiz, Tunis, Tunisia.
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MeSH Terms
Adrenergic alpha-Agonists*
Anti-Anxiety Agents*
Blood Pressure / drug effects
Catecholamines / blood*
Double-Blind Method
Heart Rate / drug effects
Hemodynamics / drug effects*
Middle Aged
Preanesthetic Medication*
Prospective Studies
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Anti-Anxiety Agents; 0/Catecholamines; 4205-90-7/Clonidine; 68-88-2/Hydroxyzine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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