| Comparison of the effects of 6- thio- and 6-methylthiopurine ribonucleoside cyclic monophosphates withtheir corresponding nucleosides on the growth of rat hepatoma cells. | |
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MedLine Citation:
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PMID: 189907 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cyclic nucleotide forms of 6-mercaptopurine and 6-methylmercaptopurine have been found to be cytotoxic to rat hepatoma cells. Studies with an inhibitor of phosphodiesterase suggest that the cytotoxicity of both cyclic nucleotides results principally from conversion to the 5'-nucleotide. A comparison of the two thiopurine cyclic nucleotides with their nucleoside counterparts has suggested that (a) the thio derivatives act by a common mechanism which is different from that exerted by the methylthio derivatives, and (b) the methylthio cyclic nucleotide acts, at least in part, by a mechanism which differs from that exerted by the methylthio nucleoside. |
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Authors:
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J W Koontz; W D Wicks |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cancer research Volume: 37 ISSN: 0008-5472 ISO Abbreviation: Cancer Res. Publication Date: 1977 Mar |
Date Detail:
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Created Date: 1977-04-15 Completed Date: 1977-04-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2984705R Medline TA: Cancer Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 651-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Carcinoma, Hepatocellular
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drug therapy*,
metabolism Cell Division / drug effects Cells, Cultured Cyclic IMP / analogs & derivatives*, pharmacology Dose-Response Relationship, Drug Inosine / analogs & derivatives* Inosine Nucleotides / analogs & derivatives* Liver Neoplasms / drug therapy*, metabolism Methylthioinosine / analogs & derivatives*, metabolism, pharmacology Neoplasms, Experimental / drug therapy, metabolism Phosphodiesterase Inhibitors Purine Nucleosides / pharmacology Thioinosine / analogs & derivatives*, metabolism, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Inosine Nucleotides; 0/Phosphodiesterase Inhibitors; 0/Purine Nucleosides; 342-69-8/Methylthioinosine; 3545-76-4/Cyclic IMP; 574-25-4/Thioinosine; 58-63-9/Inosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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