| Comparison of effectiveness of timolol administered once a day and twice a day in the control of blood pressure in essential hypertension. | |
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MedLine Citation:
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PMID: 390339 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of a single dose and of two equally divided doses of timolol were compared in a double-blind trial in 15 patients with essential hypertension. The amount of timolol per day remained constant for each patient, but individual patients received different amounts (from 10 mg to 30 mg/day). Timolol combined with a diuretic produced similar lowering of blood pressure in patients who required 10 mg, 20 mg or 30 mg of timolol per day when given either as one dose or in two equal doses. Plasma concentrations of timolol were high enough to be a major contributing factor to the long duration of the hypotensive response. |
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Authors:
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G Jennings; A Bobik; P Korner |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: The Medical journal of Australia Volume: 2 ISSN: 0025-729X ISO Abbreviation: Med. J. Aust. Publication Date: 1979 Sep |
Date Detail:
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Created Date: 1980-02-26 Completed Date: 1980-02-26 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0400714 Medline TA: Med J Aust Country: AUSTRALIA |
Other Details:
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Languages: eng Pagination: 263-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Ambulatory Care Amiloride / administration & dosage Blood Pressure / drug effects* Clinical Trials as Topic Double-Blind Method Female Heart Rate / drug effects Humans Hydrochlorothiazide / administration & dosage Hypertension / drug therapy* Male Middle Aged Placebos Posture Propanolamines / administration & dosage* Time Factors Timolol / administration & dosage*, blood |
| Chemical | |
Reg. No./Substance:
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0/Placebos; 0/Propanolamines; 2609-46-3/Amiloride; 26839-75-8/Timolol; 58-93-5/Hydrochlorothiazide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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