| Comparison of the effectiveness of dithiocarbamates on the excretion and distribution of cadmium in mice. | |
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MedLine Citation:
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PMID: 1784839 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sodium N-benzyl-D-glucamine dithiocarbamate (BGD), sodium N-p-hydroxymethylbenzyl-D-glucamine dithiocarbamate (HBGD), and sodium N-p-methoxybenzyl-D-glucamine dithiocarbamate (MeOBGD) were evaluated for their efficacy in the distribution and excretion of cadmium in mice exposed to cadmium. Mice were injected i.p. with 109CdCl2 (1 mg Cd/kg and 74 kBq of 109Cd/mouse) and 30 min or 24 h later, they were injected i.p. with chelating agents (5% of an LD50). The results of this study indicated that the injection of HBGD to mice pretreated with cadmium can remove cadmium from the body without redistribution of cadmium to the brain, testes, and heart more effectively than that of BGD or MeOBGD. |
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Authors:
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H Shimada; T Funakoshi; M Kiyozumi; S Kojima |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Research communications in chemical pathology and pharmacology Volume: 73 ISSN: 0034-5164 ISO Abbreviation: Res. Commun. Chem. Pathol. Pharmacol. Publication Date: 1991 Aug |
Date Detail:
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Created Date: 1992-03-16 Completed Date: 1992-03-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0244734 Medline TA: Res Commun Chem Pathol Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 249-52 Citation Subset: IM |
Affiliation:
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Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bile / metabolism Brain Chemistry Cadmium / pharmacokinetics*, urine Chelating Agents / analysis, pharmacology* Lethal Dose 50 Male Mice Sorbitol / analogs & derivatives*, pharmacology Thiocarbamates / pharmacology* Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Chelating Agents; 0/Thiocarbamates; 110771-92-1/N-benzylglucamine dithiocarbamate; 115459-35-3/N-(4-methoxybenzyl)glucamine dithiocarbamate; 127531-17-3/N-4-hydroxymethylbenzylglucamine dithiocarbamate; 50-70-4/Sorbitol; 7440-43-9/Cadmium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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