Document Detail


Comparison of the effectiveness of dithiocarbamates on the excretion and distribution of cadmium in mice.
MedLine Citation:
PMID:  1784839     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sodium N-benzyl-D-glucamine dithiocarbamate (BGD), sodium N-p-hydroxymethylbenzyl-D-glucamine dithiocarbamate (HBGD), and sodium N-p-methoxybenzyl-D-glucamine dithiocarbamate (MeOBGD) were evaluated for their efficacy in the distribution and excretion of cadmium in mice exposed to cadmium. Mice were injected i.p. with 109CdCl2 (1 mg Cd/kg and 74 kBq of 109Cd/mouse) and 30 min or 24 h later, they were injected i.p. with chelating agents (5% of an LD50). The results of this study indicated that the injection of HBGD to mice pretreated with cadmium can remove cadmium from the body without redistribution of cadmium to the brain, testes, and heart more effectively than that of BGD or MeOBGD.
Authors:
H Shimada; T Funakoshi; M Kiyozumi; S Kojima
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Research communications in chemical pathology and pharmacology     Volume:  73     ISSN:  0034-5164     ISO Abbreviation:  Res. Commun. Chem. Pathol. Pharmacol.     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1992-03-16     Completed Date:  1992-03-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0244734     Medline TA:  Res Commun Chem Pathol Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  249-52     Citation Subset:  IM    
Affiliation:
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bile / metabolism
Brain Chemistry
Cadmium / pharmacokinetics*,  urine
Chelating Agents / analysis,  pharmacology*
Lethal Dose 50
Male
Mice
Sorbitol / analogs & derivatives*,  pharmacology
Thiocarbamates / pharmacology*
Tissue Distribution
Chemical
Reg. No./Substance:
0/Chelating Agents; 0/Thiocarbamates; 110771-92-1/N-benzylglucamine dithiocarbamate; 115459-35-3/N-(4-methoxybenzyl)glucamine dithiocarbamate; 127531-17-3/N-4-hydroxymethylbenzylglucamine dithiocarbamate; 50-70-4/Sorbitol; 7440-43-9/Cadmium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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