| Comparison of the effect of various chemical peeling agents in a mini-pig model. | |
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MedLine Citation:
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PMID: 8634804 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: With the advent of newer chemical peels, there is now a wide range of peeling agents that can be applied on specific patients. OBJECTIVE: The purpose of this study was to closely examine the more common chemical peeling agents at different concentrations. METHODS: The study methods were carried out by thoroughly cleansing the skin surface with acetone. Different concentrations of the chemical peels were applied on different skin areas (2 x 2 cm each) and left on the skin for 15 minutes: phenol-Bakers, 25%, 50%, 75%, 88%; trichloroacetic acid, 25%, 50%, 75%; glycolic acid, 50%, 70%; and pyruvic acid, 50%, 100%. Serial biopsies were taken from each peeling site at 1, 7, and 21 days post-peel. Biopsies were then evaluated for epidermal changes, inflammation, and collagen deposition. RESULTS: The results show that Bakers phenol peel caused the most inflammation and nonspecific reaction, and in addition, a proportionate amount of new collagen deposition. Plus, increasing concentrations of phenol and TCA caused increasing amount of epidermal sloughing and inflammation after 1 day post-peel. The extent of reaction from the phenol and TCA was directly proportional to the collagen deposition at 21 days. CONCLUSIONS: The glycolic acid and pyruvic acid caused minimal nonspecific reaction. However, the collagen deposition caused by the glycolic acid and pyruvic acid was disproportionately increased suggesting a direct stimulatory effect by the two agents. |
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Authors:
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L S Moy; S Peace; R L Moy |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] Volume: 22 ISSN: 1076-0512 ISO Abbreviation: Dermatol Surg Publication Date: 1996 May |
Date Detail:
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Created Date: 1996-07-08 Completed Date: 1996-07-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9504371 Medline TA: Dermatol Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 429-32 Citation Subset: IM |
Affiliation:
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Department of Medicine, UCLA School of Medicine, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chemexfoliation* Collagen / metabolism Drug Evaluation Glycolates / administration & dosage, pharmacology* Phenol Phenols / administration & dosage, pharmacology* Pyruvates* / administration & dosage, pharmacology* Pyruvic Acid Skin / drug effects, metabolism Swine Swine, Miniature Time Factors Trichloroacetic Acid / administration & dosage, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Glycolates; 0/Phenols; 0/Pyruvates; 108-95-2/Phenol; 127-17-3/Pyruvic Acid; 76-03-9/Trichloroacetic Acid; 79-14-1/glycolic acid; 9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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