Document Detail

Comparison of the effect of various chemical peeling agents in a mini-pig model.
MedLine Citation:
PMID:  8634804     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: With the advent of newer chemical peels, there is now a wide range of peeling agents that can be applied on specific patients. OBJECTIVE: The purpose of this study was to closely examine the more common chemical peeling agents at different concentrations. METHODS: The study methods were carried out by thoroughly cleansing the skin surface with acetone. Different concentrations of the chemical peels were applied on different skin areas (2 x 2 cm each) and left on the skin for 15 minutes: phenol-Bakers, 25%, 50%, 75%, 88%; trichloroacetic acid, 25%, 50%, 75%; glycolic acid, 50%, 70%; and pyruvic acid, 50%, 100%. Serial biopsies were taken from each peeling site at 1, 7, and 21 days post-peel. Biopsies were then evaluated for epidermal changes, inflammation, and collagen deposition. RESULTS: The results show that Bakers phenol peel caused the most inflammation and nonspecific reaction, and in addition, a proportionate amount of new collagen deposition. Plus, increasing concentrations of phenol and TCA caused increasing amount of epidermal sloughing and inflammation after 1 day post-peel. The extent of reaction from the phenol and TCA was directly proportional to the collagen deposition at 21 days. CONCLUSIONS: The glycolic acid and pyruvic acid caused minimal nonspecific reaction. However, the collagen deposition caused by the glycolic acid and pyruvic acid was disproportionately increased suggesting a direct stimulatory effect by the two agents.
L S Moy; S Peace; R L Moy
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]     Volume:  22     ISSN:  1076-0512     ISO Abbreviation:  Dermatol Surg     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-07-08     Completed Date:  1996-07-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9504371     Medline TA:  Dermatol Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  429-32     Citation Subset:  IM    
Department of Medicine, UCLA School of Medicine, USA.
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MeSH Terms
Collagen / metabolism
Drug Evaluation
Glycolates / administration & dosage,  pharmacology*
Phenols / administration & dosage,  pharmacology*
Pyruvates* / administration & dosage,  pharmacology*
Pyruvic Acid
Skin / drug effects,  metabolism
Swine, Miniature
Time Factors
Trichloroacetic Acid / administration & dosage,  pharmacology*
Reg. No./Substance:
0/Glycolates; 0/Phenols; 0/Pyruvates; 108-95-2/Phenol; 127-17-3/Pyruvic Acid; 76-03-9/Trichloroacetic Acid; 79-14-1/glycolic acid; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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