| Comparison of the effect of midazolam or vecuronium on blood pressure and cerebral blood flow velocity in the premature newborn. | |
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MedLine Citation:
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PMID: 1364197 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of midazolam and vecuronium on mean arterial pressure (MAP) and mean cerebral blood flow velocity (MCBFV) was evaluated in premature infants (birthweight 550-2,560 g; gestational age 26-36 weeks) randomised to receive either 0.1 mg/kg midazolam (n = 7) or 0.05 mg/kg vecuronium (n = 8) intravenously. MAP, by means of an indwelling arterial catheter, and MCBFV, by means of non-invasive pulsed-Doppler of the middle cerebral artery, were measured every 5 min, starting at 10 min prior to until 1 h after drug administration. A transient 25-43% decrease in MCBFV (mean 0.06 m/s) dependent on a 8-23% decrease in blood pressure (mean 9 mm Hg) was noted in all patients within 15 min following administration of midazolam, which returned to baseline values within 1 h. In 2 out of 7 infants, a plasma expander was required. In contrast, vecuronium only decreased the MCBFV in 3 of 8 infants. Thus, a bolus of midazolam transiently decreased blood pressure and MCBFV, and should be used cautiously in sick preterm infants. |
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Authors:
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H L van Straaten; C M Rademaker; L S de Vries |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Developmental pharmacology and therapeutics Volume: 19 ISSN: 0379-8305 ISO Abbreviation: Dev Pharmacol Ther Publication Date: 1992 |
Date Detail:
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Created Date: 1994-03-16 Completed Date: 1994-03-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8003947 Medline TA: Dev Pharmacol Ther Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 191-5 Citation Subset: IM |
Affiliation:
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Department of Neonatology, University Children's Hospital, Het Wilhelmina Kinderziekenhuis, Utrecht, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Flow Velocity
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drug effects Blood Pressure / drug effects* Cerebrovascular Circulation / drug effects* Humans Infant, Newborn Infant, Premature* Midazolam / pharmacology* Vecuronium Bromide / pharmacology* |
| Chemical | |
Reg. No./Substance:
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50700-72-6/Vecuronium Bromide; 59467-70-8/Midazolam |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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