Document Detail

Comparison of the effect of an equimolar and low dose of fenitrothion and methylparathion on their own metabolism in rat liver.
MedLine Citation:
PMID:  7097808     Owner:  NLM     Status:  MEDLINE    
The effects of fenitrothion and methylparathion on the activities of cholinesterase and hepatic microsomal monooxygenases were investigated and compared following a single or repeated oral administration of an equimolar and low dose of the insecticides. The activities of cholinesterase in brain and plasma were inhibited equally by the repetitive administration of both insecticides. Aminopyrine N-demethylase activity and cyt.P-450 content were not affected under the same experimental conditions. However, methylparathion, when given repeatedly, inhibited the dearylation and desulfuration of it own. The results may indicate that low dose continuous exposure to methylparathion could cause the depression of its own metabolism in rat.
T Yamamoto; T Egashira; T Yoshida; Y Kuroiwa
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of toxicological sciences     Volume:  7     ISSN:  0388-1350     ISO Abbreviation:  J Toxicol Sci     Publication Date:  1982 Feb 
Date Detail:
Created Date:  1982-09-24     Completed Date:  1982-09-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7805798     Medline TA:  J Toxicol Sci     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  35-41     Citation Subset:  IM    
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MeSH Terms
Cholinesterase Inhibitors*
Dose-Response Relationship, Drug
Fenitrothion / metabolism*,  toxicity
Methyl Parathion / metabolism*,  toxicity
Microsomes, Liver / enzymology*
Oxygenases / metabolism*
Parathion / analogs & derivatives*
Rats, Inbred Strains
Reg. No./Substance:
0/Cholinesterase Inhibitors; 122-14-5/Fenitrothion; 298-00-0/Methyl Parathion; 56-38-2/Parathion; EC 1.13.-/Oxygenases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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