| Comparison of the effect of aminophylline and low PEEP vs. high PEEP on EGF concentration in critically ill patients with ALI/ARDS. | |
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MedLine Citation:
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PMID: 15811166 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Acute respiratory distress syndrome (ARDS) remains a serious, often fatal, condition, despite progress in modern critical care treatment. Cytokines play important roles in the pathogenesis of the syndrome, although their roles in the evaluation and outcome have not been clearly elucidated yet. OBJECTIVES: We tested whether serum concentration of epidermal growth factor (EGF), as one of the important inflammatory mediators, changes with time and administration of mechanical ventilation and aminophylline. PATIENTS AND METHODS: Thirty patients [mean (SD): age = 56.6 (17.4) years] with ARDS were enrolled. After diagnosis based on inclusion and exclusion criteria, the patients were intubated and mechanically ventilated. Two hours after ventilation with definite positive end-expiratory pressure (PEEP), aminophylline with a specific dose was started. Serum samples were obtained at five time points of 0, 2, 2.5, 4 and 8 h post-starting PEEP. RESULTS: Serum EGF concentration decreased after mechanical ventilation with PEEP (P < 0.05). The serum EGF concentrations 8 h after intervention was statistically lower in the low PEEP group than in the high PEEP group. The Acute Physiology and Chronic Health Evaluation (APACHE) Pi score and PaO2/FiO2 improved significantly after 8 h (P < 0.05). CONCLUSION: Beneficial effects of mechanical ventilation and aminophylline on APACHE Pi score and PaO2/FiO2 influence serum EGF levels. These findings may have relevance to the development of multisystem organ failure. |
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Authors:
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P Salari; M Mojtahedzadeh; A Najafi; S Sadraie; K Bahaadini; M Moharreri; N Hadavand; M Abdollahi |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of clinical pharmacy and therapeutics Volume: 30 ISSN: 0269-4727 ISO Abbreviation: J Clin Pharm Ther Publication Date: 2005 Apr |
Date Detail:
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Created Date: 2005-04-06 Completed Date: 2005-11-03 Revised Date: 2008-05-28 |
Medline Journal Info:
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Nlm Unique ID: 8704308 Medline TA: J Clin Pharm Ther Country: England |
Other Details:
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Languages: eng Pagination: 139-44 Citation Subset: IM |
Affiliation:
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School of Pharmacy and Pharmaceutical Sciences Research Centre, Tehran University of Medical Sciences, Tehran, Iran. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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APACHE Aminophylline / administration & dosage, blood, therapeutic use* Critical Illness* Epidermal Growth Factor / blood*, drug effects Female Humans Injections, Intravenous Intensive Care Units Male Middle Aged Outcome Assessment (Health Care) / methods, statistics & numerical data Oxygen / analysis, blood, physiology Partial Pressure Patient Selection Positive-Pressure Respiration / methods* Respiratory Distress Syndrome, Adult / blood*, drug therapy, mortality Time Factors |
| Chemical | |
Reg. No./Substance:
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317-34-0/Aminophylline; 62229-50-9/Epidermal Growth Factor; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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