Document Detail


Comparison of edge vascular response after sirolimus- and paclitaxel-eluting stent implantation.
MedLine Citation:
PMID:  21903281     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: To compare the edges vascular response, we analyzed the intravascular ultrasound (IVUS) parameters after implantation of the sirolimus-eluting stent (SES) or the paclitaxel-eluting stent (PES). METHODS: Two hundred-two angina patients (123 men; 61.5±9.2years of age, SES: n=91, PES: n=111) were enrolled. Both edge segments of the stent were analyzed. The change (Δ) of each parameter at follow-up was calculated. RESULTS: The edge restenosis rate was higher in the PES group. However, the Δ Vessel, Δ Plaque and Δ Lumen volume at 5mm edge segments were not different between the two groups except the Δ Plaque volume at the distal segment, higher in the PES than the SES group (6.6±15.7 vs. 1.0±13.1mm(3), P=.016). In the PES group, lumen area at the both 1mm edge segments decreased because of plaque progression (proximal, 1.9±1.5 to 2.2±2.0mm(2), P=.095; distal, 0.6±1.1 to 1.0±1.4mm(2), P=.018) with negative remodeling (proximal, 9.9±2.4 to 9.4±2.6mm(2), P=.004; distal, 7.6±2.4 to 7.2±2.4mm(2), P=.052). Conversely, lumen area at these segments increased due to plaque regression (proximal, 3.2±1.8 to 2.1±1.6mm(2), P=.000; distal, 1.5±1.4 to 0.9±1.3mm(2), P=.000) even though there was negative remodeling in the SES group (proximal, 10.1±2.4 to 9.6±2.3mm(2), P=.019; distal, 7.8±2.3 to 7.5±2.3mm(2), P=.074). The Δ Plaque and Δ Lumen area at the both 1mm edge segments were more prominent in the PES group. CONCLUSIONS: Compared to SES, PES was associated with luminal reduction accompanied by plaque progression with negative remodeling at edge segments.
Authors:
Woong Chol Kang; Yae Min Park; Kwen-Chul Shin; Chan Il Moon; Kyounghoon Lee; Seung Hwan Han; Mi Seung Shin; Jeonggeun Moon; Taehoon Ahn; Eak Kyun Shin
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-6
Journal Detail:
Title:  International journal of cardiology     Volume:  -     ISSN:  1874-1754     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
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