| Comparison of early lung clearance of yellowcake aerosols in rats with in vitro dissolution and IR analysis. | |
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MedLine Citation:
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PMID: 6706593 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The lung retention of uranium was determined in rats that inhaled aerosols of commercial yellowcake powders obtained from two mills (Mill A and Mill D) and whose chemical composition and solubilities in vitro were significantly different. Analysis by IR absorption indicated Mill A yellowcake contained 82% ammonium diuranate (ADU) and 18% U3O8. The Mill D powder contained 25% ADU and 75% U3O8. In vitro dissolution studies indicated for the Mill A sample, approximately 85% of the uranium had a dissolution half-time (T 1/2) of less than one day, with the remainder dissolving with a half-time of 500 days. For the Mill D sample, 25% had T 1/2 less than one day and 75% had T 1/2 of 300 days. Groups of 50 rats were exposed by nose-only inhalation to aerosols of either the Mill A or the Mill D yellowcake. Rats were sacrificed in groups of five at intervals through six months after exposure. Selected tissues and excreta samples were assayed by fluorometry to determine their uranium contents. For the Mill A yellowcake, 78% initial lung (broncho-alveolar) burden cleared with T 1/2 of 0.5 days, and 22% with T 1/2 of 240 days. For the Mill D yellowcake, 25% initial lung burden cleared with T 1/2 of 3.5 days and 75% with T 1/2 of 110 days. Thus, the lung clearance of uranium in the rat mimicked the in vitro dissolution data and supported the contention that ADU should be considered as a Class D compound (T 1/2 = 0.5 days) and U3O8 behaves in the lung as a Class Y (T 1/2 greater than 100 days) material. |
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Authors:
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E G Damon; A F Eidson; F F Hahn; W C Griffith; R A Guilmette |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Health physics Volume: 46 ISSN: 0017-9078 ISO Abbreviation: Health Phys Publication Date: 1984 Apr |
Date Detail:
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Created Date: 1984-05-23 Completed Date: 1984-05-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985093R Medline TA: Health Phys Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 859-66 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aerosols Animals Environmental Exposure Female Fluorometry Lung / metabolism* Male Metallurgy* Rats Rats, Inbred F344 Spectrophotometry, Infrared Uranium / administration & dosage, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Aerosols; 7440-61-1/Uranium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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