Document Detail

Comparison of dual- and triple-freeze protocols for hepatic cryoablation in a Tibet pig model.
MedLine Citation:
PMID:  22561141     Owner:  NLM     Status:  Publisher    
The purpose of this study was to compare a dual-freeze protocol with a triple-freeze protocol for hepatic cryoablation in a porcine model. Eighteen cryoablations were performed over an exposed operation field in nine normal porcine livers, using dual- (10-5-10-5) and triple-freeze (5-5-5-5-10-5) protocols. Changes in the temperature of the cryoprobes and the diameter of the iceballs were recorded during the ablation, and pathological changes in the cryozones (zones of tissue destruction) were assessed seven days after the procedure. Use of two and three freeze-thaw cycles produced iceballs of different diameters. Seven days after cryosurgery, the triple-freeze protocol was associated with a larger zone of complete necrosis than the dual-freeze protocol, although the two protocols produced cryozones and cryolesions of similar length, and in both cases the cryozones contained five areas of destruction. With the same freezing time (20min), the triple-freeze protocol may be a more powerful liver ablation method than the dual-freeze protocol.
Jialaing Li; Jibing Chen; Liang Zhou; Jianying Zeng; Fei Yao; Binghui Wu; Gang Fang; Chunjuan Deng; Zhixian Chen; Yin Leng; Keqiang Xu; Lizhi Niu; Jiansheng Zuo; Kecheng Xu
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-25
Journal Detail:
Title:  Cryobiology     Volume:  -     ISSN:  1090-2392     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-5-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0006252     Medline TA:  Cryobiology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Guangzhou Fuda Cancer Hospital, No. 2 Tangdexi Road, Tianhe District, Guangzhou 510305, China; Guangzhou Fuda Hospital, No. 91-93 Judezhong Road, Haizhu District, Guangzhou 510305, China.
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