Document Detail

Comparison of dual-energy CT-derived iodine content and iodine overlay of normal, inflammatory and metastatic squamous cell carcinoma cervical lymph nodes.
MedLine Citation:
PMID:  24081649     Owner:  NLM     Status:  Publisher    
OBJECTIVES: To evaluate whether dual-energy computed tomography (DECT)-derived iodine content and iodine overlay could differentiate between normal, inflammatory and metastatic squamous cell carcinoma (SCC) cervical lymph nodes.
METHODS: This study was approved by the institutional review board. Sixteen patients with normal lymph nodes, 20 patients with enlarged nodes draining deep cervical inflammations and 23 patients with pathologically proved metastatic SCC nodes who underwent contrast enhanced DECT were retrospectively identified. Iodine content and overlay of 36 normal, 43 inflammatory and 52 metastatic lymph nodes were calculated using circular regions of interest and compared among the three groups. A receiver operating characteristic (ROC) curve was used to determine the sensitivity and specificity of iodine content and overlay for diagnosis of metastatic nodes.
RESULTS: Iodine content (mg/ml) was significantly lower for metastatic lymph nodes (2.34 ± 0.45) than for normal (2.86 ± 0.37) and inflammatory (3.53 ± 0.56) lymph nodes, P < 0.0001. Iodine overlay (HU) was also significantly lower for metastatic lymph nodes (47 ± 11.6) than normal (57.4 ± 8.2) and inflammatory nodes (69.3 ± 11.5), P < 0.0001. The areas under the ROC curve for iodine content and iodine overlay were 0.923 and 0.896.
CONCLUSIONS: DECT-derived iodine content and overlay differ significantly among normal, inflammatory and metastatic SCC cervical lymph nodes.
KEY POINTS: • Derived iodine content can be calculated from contrast-enhanced dual-energy CT. • Derived iodine content and iodine overlay could help characterise cervical lymph nodes. • Iodine parameters were significantly lower in metastatic lymph nodes than normal/inflammatory lymph nodes. • Iodine content appears more sensitive than iodine overlay for lymph node characterisation.
Ahmed M Tawfik; A A Razek; J Matthias Kerl; N E Nour-Eldin; Ralf Bauer; Thomas J Vogl
Related Documents :
23151319 - Tumorigenesis role and clinical significance of dj-1, a negative regulator of pten, in ...
24714739 - Gastric malt lymphoma: old and new insights.
20678359 - Making evidence available: prognostic classification systems.
11493099 - Predictive model for immunotherapy of alopecia areata with diphencyprone.
15063229 - Histological determinants of survival in completely resected t1-2n1m0 nonsmall cell can...
23001329 - Invasion of the inner and outer layers of the visceral pleura in pt1 size lung adenocar...
21173289 - Racial/ethnic disparities in access to care and survival for patients with early-stage ...
10612219 - Dose- intensified, preoperative and adjuvant chemotherapy in patients with t3- and t4- ...
1944989 - Local treatment of liver metastases with recombinant tumour necrosis factor (rtnf): a p...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-10-2
Journal Detail:
Title:  European radiology     Volume:  -     ISSN:  1432-1084     ISO Abbreviation:  Eur Radiol     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-10-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9114774     Medline TA:  Eur Radiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Diagnostic and Interventional Radiology, Johan Wolfgang Goethe University Hospital, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Hessen, Germany,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Potential role of shear-wave ultrasound elastography for the differential diagnosis of breast non-ma...
Next Document:  Small scale membrane mechanics.