| Comparison of the disposition of butadiene epoxides in Sprague-Dawley rats and B6C3F1 mice following a single and repeated exposures to 1,3-butadiene via inhalation. | |
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MedLine Citation:
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PMID: 9347927 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1,3-Butadiene (BD), a compound used extensively in the rubber industry, is a potent carcinogen in mice and a weak carcinogen in rats in chronic carcinogenicity bioassays. While many chemicals are known to alter their own metabolism after repeated exposures, the effect of exposure prior to BD on its in vivo metabolism has not been reported. The purpose of the present research was to examine the effect of repeated exposure to BD on tissue concentrations of two mutagenic BD metabolites, butadiene monoepoxide (BDO) and butadiene diepoxide (BDO2). Concentrations of BD epoxides were compared in several tissues of rats and mice following a single exposure or ten repeated exposures to a target concentration of 62.5 ppm BD. Female Sprague-Dawley rats and female B6C3F1 mice were exposed to BD for 6 h or 6 h x 10 days. BDO and BDO2 were quantified in blood and several other tissues following preparation by cryogenic vacuum distillation and analysis by multidimensional gas chromatography-mass spectrometry. Blood and lung BDO concentrations did not differ significantly (P < or = 0.05) between the two exposure regimens in either species. Following multiple exposures to BD, BDO levels were 5- and 1.6-fold higher (P < or = 0.05) in mammary tissue and 2- and 1.4-fold higher in fat tissue of rats and mice, respectively, as compared with single exposures. BDO2 levels also increased in rat fat tissue following multiple exposures to BD. However, in mice, levels of this metabolite decreased by 15% in fat, by 28% in mammary tissue and by 34% in lung tissue following repeated exposures to BD. The finding that the mutagenic epoxide BDO, which is the precursor to the highly mutagenic BDO2, accumulates in rodent fat may be important in assessing the potential risk to humans from inhalation of BD. |
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Authors:
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J R Thornton-Manning; A R Dahl; W E Bechtold; W C Griffith; R F Henderson |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Toxicology Volume: 123 ISSN: 0300-483X ISO Abbreviation: Toxicology Publication Date: 1997 Nov |
Date Detail:
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Created Date: 1997-11-06 Completed Date: 1997-11-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0361055 Medline TA: Toxicology Country: IRELAND |
Other Details:
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Languages: eng Pagination: 125-34 Citation Subset: IM |
Affiliation:
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Lovelace Respiratory Research Institute, Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM 87185, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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metabolism Administration, Inhalation Animals Butadienes / administration & dosage, metabolism, toxicity* Carcinogens / administration & dosage, metabolism, toxicity* Epoxy Compounds / blood, metabolism* Female Femur / metabolism Lung / metabolism Mammary Glands, Animal / metabolism Mice Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Butadienes; 0/Carcinogens; 0/Epoxy Compounds; 106-99-0/1,3-butadiene; 1464-53-5/erythritol anhydride; 930-22-3/3,4-epoxy-1-butene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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