| Comparison of directly stimulated with axon-reflex-mediated sudomotor responses in human subjects and in patients with diabetes. | |
| | |
MedLine Citation:
|
PMID: 8502263 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The muscarinic receptors of human eccrine sweat gland may be directly stimulated by iontophoresis of acetylcholine (direct response; DIR) and indirectly via nicotinic receptors and an axon "reflex" (AXR). Using a specially designed multicompartmental sweat cell and dual sudorometers, we were able to simultaneously record the evoked DIR and AXR responses. On a second day, we repeated the experiment under identical ambient and stimulus conditions but instead obtained silastic imprints of DIR and AXR for morphometry. Studies were done on 24 controls (mean +/- SD = 47.6 +/- 15.1 years) and 23 diabetic subjects (mean +/- SD = 49.6 +/- 16.3 years). In control subjects, sudorometric DIR recordings were consistently larger than AXR. There was no difference in sweat droplet density by sex, but the size of droplets was larger in males. In diabetic patients 3 of 23 had absent AXR but preserved DIR, suggesting that failure of AXR preceded DIR in patients with neuropathy. Patients with mild neuropathy had an overrepresentation of large diameter droplets in the silastic imprints of both DIR and AXR, while patients with severe neuropathy had a markedly reduced density and small diameter droplets. |
| | |
Authors:
|
M Kihara; T L Opfer-Gehrking; P A Low |
Related Documents
:
|
20127893 - Experienced clinicians improve detection of third and fourth heart sounds by viewing ac... 10122873 - The use of the medical record and financial data to examine the cost of infections in t... 1549513 - Fishbein's model of reasoned action and compliance behavior of hypertensive patients. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Muscle & nerve Volume: 16 ISSN: 0148-639X ISO Abbreviation: Muscle Nerve Publication Date: 1993 Jun |
Date Detail:
|
Created Date: 1993-06-28 Completed Date: 1993-06-28 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 7803146 Medline TA: Muscle Nerve Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 655-60 Citation Subset: IM |
Affiliation:
|
Department of Neurology, Mayo Foundation, Rochester, Minnesota. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acetylcholine
/
pharmacology Autonomic Nervous System / physiopathology Diabetic Neuropathies / physiopathology* Female Heart / physiopathology Humans Male Middle Aged Receptors, Nicotinic / drug effects, physiology Sex Characteristics Stimulation, Chemical Sweat / secretion* Sweat Glands / physiopathology* Sweating / drug effects, physiology* |
| Grant Support | |
ID/Acronym/Agency:
|
NINCDS NO1 NS72392/NS/NINDS NIH HHS; NINCDS NS14302/NS/NINDS NIH HHS; NINCDS RO1 NS22352/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Receptors, Nicotinic; 51-84-3/Acetylcholine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Association of IgG anti-GD1a antibody with severe Guillain-Barré syndrome.
Next Document: Discharge properties of single motor units in patients with spinal cord injuries.