Document Detail


Comparison of directly stimulated with axon-reflex-mediated sudomotor responses in human subjects and in patients with diabetes.
MedLine Citation:
PMID:  8502263     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The muscarinic receptors of human eccrine sweat gland may be directly stimulated by iontophoresis of acetylcholine (direct response; DIR) and indirectly via nicotinic receptors and an axon "reflex" (AXR). Using a specially designed multicompartmental sweat cell and dual sudorometers, we were able to simultaneously record the evoked DIR and AXR responses. On a second day, we repeated the experiment under identical ambient and stimulus conditions but instead obtained silastic imprints of DIR and AXR for morphometry. Studies were done on 24 controls (mean +/- SD = 47.6 +/- 15.1 years) and 23 diabetic subjects (mean +/- SD = 49.6 +/- 16.3 years). In control subjects, sudorometric DIR recordings were consistently larger than AXR. There was no difference in sweat droplet density by sex, but the size of droplets was larger in males. In diabetic patients 3 of 23 had absent AXR but preserved DIR, suggesting that failure of AXR preceded DIR in patients with neuropathy. Patients with mild neuropathy had an overrepresentation of large diameter droplets in the silastic imprints of both DIR and AXR, while patients with severe neuropathy had a markedly reduced density and small diameter droplets.
Authors:
M Kihara; T L Opfer-Gehrking; P A Low
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Muscle & nerve     Volume:  16     ISSN:  0148-639X     ISO Abbreviation:  Muscle Nerve     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-06-28     Completed Date:  1993-06-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  655-60     Citation Subset:  IM    
Affiliation:
Department of Neurology, Mayo Foundation, Rochester, Minnesota.
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / pharmacology
Autonomic Nervous System / physiopathology
Diabetic Neuropathies / physiopathology*
Female
Heart / physiopathology
Humans
Male
Middle Aged
Receptors, Nicotinic / drug effects,  physiology
Sex Characteristics
Stimulation, Chemical
Sweat / secretion*
Sweat Glands / physiopathology*
Sweating / drug effects,  physiology*
Grant Support
ID/Acronym/Agency:
NINCDS NO1 NS72392/NS/NINDS NIH HHS; NINCDS NS14302/NS/NINDS NIH HHS; NINCDS RO1 NS22352/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Nicotinic; 51-84-3/Acetylcholine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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