Document Detail

Comparison of the digitalis receptor in erythrocytes from preterm infants and adults.
MedLine Citation:
PMID:  2836786     Owner:  NLM     Status:  MEDLINE    
We compared 86rubidium by erythrocytes of preterm infants and adults as a measurement of their Na+, K+, ATPase enzyme system. In neonates, total uptake (0.92 +/- 0.13 micrograms/10(6) cells) and specific uptake (0.64 +/- 0.076 micrograms/10(6) cells) were significantly higher than in adults (0.52 +/- 0.1 and 0.29 +/- 0.06 micrograms/10(6) cells, respectively; p less than 0.025). The percentage of specific uptake from total uptake was higher in infants (73.3 +/- 2.3%) than in adults (57.9 +/- 4.6%) (p less than 0.005). No differences were found in the affinity constant of 86Rb uptake between infants (4.35 +/- 0.48 ng/ml) and adults (4.85 +/- 0.48 ng/ml). Stratification of infants according to their serum K+ concentrations revealed that levels above 5.4 mEq/liter were associated with a higher specific uptake (0.79 +/- 0.107 micrograms/10(6) cells) than in normokalemic infants (0.54 +/- 0.09 micrograms/10(6) cells) or adults (0.304 +/- 0.061 micrograms/10(6) cells) (p less than 0.05). The difference between hyperkalemic and normokalemic infants persisted after excluding those who received adult packed cells (0.88 +/- 0.1 and 0.6 +/- 0.12 micrograms/10(6) cells, respectively) (p less than 0.05). Infants with serum K+ greater than 5.8 mEq/liter received on average significantly more K+ in previous days (2.46 +/- 0.49 versus 1.13 + 0.34 mEq/; p less than 0.025). The different K+ level could not be attributed to different creatinine clearance in the two groups.
G Koren; D Long; J Klein; D Beatie; M Bologa-Campeanu; A Livne; H Kirpalani
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  23     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1988 Apr 
Date Detail:
Created Date:  1988-06-30     Completed Date:  1988-06-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  414-7     Citation Subset:  IM    
Division of Clinical Pharmacology, Hospital for Sick Children, Toronto, Ontario, Canada.
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MeSH Terms
Digitalis / metabolism*
Erythrocytes / enzymology,  ultrastructure*
Gestational Age
Infant, Newborn
Infant, Premature / physiology*
Plants, Medicinal*
Plants, Toxic*
Potassium / blood,  urine
Receptors, Drug / metabolism*
Rubidium / metabolism
Sodium-Potassium-Exchanging ATPase / metabolism
Reg. No./Substance:
0/Receptors, Drug; 0/digitalis receptor; 7440-09-7/Potassium; 7440-17-7/Rubidium; EC ATPase

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