Document Detail

Comparison of different treatment modalities of endometriosis in infertile women.
MedLine Citation:
PMID:  2947817     Owner:  NLM     Status:  MEDLINE    
This study was designed to evaluate the effectiveness of three therapeutic modalities in the management of stage I and II endometriosis. Management modalities consisted of no treatment (controls, n = 56); oral medroxyprogesterone acetate (MPA), 30 mg orally per day for 90 days (n = 36); and danazol, 600 to 800 mg daily for 6 months (n = 52). All patients were followed for at least 18 months of exposure to pregnancy. Cumulative pregnancy rates were determined by life-table analysis. At 30 months, pregnancies resulted in 55% of group I (controls), 71% of group II (MPA), and 46% of group III (danazol). There were no significant differences among these rates. Similarly, there was no significant difference between the cumulative pregnancy rates for stage I (59%) and for stage II (57%). Abortion rates for the various treatment modalities were the following: MPA 6.3%, danazol 11%, and no treatment, 14.3%. The spontaneous abortion rate in stage I and stage II disease was not significantly different. The results of this study suggest that a period of expectant management with correction of other infertility factors may be warranted in patients with mild to moderate endometriosis before medical therapy is contemplated.
M E Hull; K S Moghissi; D F Magyar; M F Hayes
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Fertility and sterility     Volume:  47     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1987 Jan 
Date Detail:
Created Date:  1987-02-19     Completed Date:  1987-02-19     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  40-4     Citation Subset:  IM    
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MeSH Terms
Antineoplastic Agents / therapeutic use
Danazol / therapeutic use*
Endometriosis / complications,  drug therapy*
Follow-Up Studies
Infertility, Female / drug therapy,  etiology*
Medroxyprogesterone / analogs & derivatives*,  therapeutic use
Medroxyprogesterone Acetate
Pelvic Neoplasms / complications,  drug therapy*
Pregnadienes / therapeutic use*
Reg. No./Substance:
0/Antineoplastic Agents; 0/Pregnadienes; 17230-88-5/Danazol; 520-85-4/Medroxyprogesterone; 71-58-9/Medroxyprogesterone Acetate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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