Document Detail

Comparison of different oxygen exchange models.
MedLine Citation:
PMID:  8523907     Owner:  NLM     Status:  MEDLINE    
A functional distribution of coronary volume can be estimated from the response of arterio-venous O2 content difference (AVO2) to a flow step. However, the results depend on the assumed O2 exchange model. The previously used model consisted of a single mixed compartment with O2 exchange (reference model). The purpose of this study is to provide an estimate of the errors made in the volume estimations by not taking into account factors as flow heterogeneity, different mixing sites or Krogh-like O2 exchange. The approach is indirect: the response of the AVO2 to a flow step has been calculated with alternative O2 exchange models in which factors mentioned are incorporated. These transients are fitted with the reference model. The resulting estimated volumes are different from the volumes assumed in the alternative models. Large differences are obtained with some of the alternative models, e.g. the model with Krogh characteristics. However, these models seem unrealistic because capillary pO2 is higher than venous pO2. Only small differences in volume are obtained with the more realistic models. Therefore, these results indicate that the coronary volumes are approximated well by the estimations obtained with the reference model. These volume estimations were 9.9 and 3.8 ml 100 g-1 for the O2 exchange vessels and the distal venous volume, respectively.
C P Van der Ploeg; J Dankelman; H G Stassen; J A Spaan
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Medical & biological engineering & computing     Volume:  33     ISSN:  0140-0118     ISO Abbreviation:  Med Biol Eng Comput     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1996-01-25     Completed Date:  1996-01-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7704869     Medline TA:  Med Biol Eng Comput     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  661-8     Citation Subset:  IM    
Laboratory for Measurement and Contrey, Faculty of Mechanical Engineering and Marine Technology, Delft University of Technology, The Netherlands.
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MeSH Terms
Blood Volume
Models, Cardiovascular*
Myocardium / metabolism*
Oxygen / blood*
Oxygen Consumption
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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