Document Detail

Comparison of different maximum safe levels in fortified foods and supplements using a probabilistic risk assessment approach.
MedLine Citation:
PMID:  20673377     Owner:  NLM     Status:  MEDLINE    
Different European institutions have developed mathematical models to propose maximum safe levels either for fortified foods or for dietary supplements. The objective of the present study was to compare and check the safety of these different maximum safe levels (MSL) by using a probabilistic risk assessment approach. The potential maximum nutritional intakes were estimated by taking into account all sources of intakes (base diet, fortified foods and dietary supplements) and compared with the tolerable upper intake levels for vitamins and minerals. This approach simulated the consequences of both food fortification and supplementation in terms of food safety. Different scenarios were tested. They are the result of the combination of several MSL obtained using the previous models. The study was based on the second French Individual and National Study on Food Consumption performed in 2006-7, matched with the French food nutritional composition database. The analyses were based on a sample of 1918 adults aged 18-79 years. Some MSL in fortified foods and dietary supplements obtained independently were protective enough, although some others could lead to nutritional intakes above the tolerable upper intake levels. The simulation showed that it is crucial to consider the inter-individual variability of fortified food intakes when setting MSL for foods and supplements. The risk assessment approach developed here by integrating the MSL for fortified foods and dietary supplements is useful for ensuring consumer protection. It may be subsequently used to test any other MSL for vitamins and minerals proposed in the future.
Ariane Dufour; Sandrine Wetzler; Mathilde Touvier; Sandrine Lioret; Jennifer Gioda; Lionel Lafay; Carine Dubuisson; Gloria Calamassi-Tran; Esther Kalonji; Irène Margaritis; Jean-Luc Volatier
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-02
Journal Detail:
Title:  The British journal of nutrition     Volume:  104     ISSN:  1475-2662     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-03     Completed Date:  2011-01-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  1848-57     Citation Subset:  IM    
Dietary Survey Unit - Nutritional Epidemiology, French Agency for Food, Environmental and Occupational Health Safety, Maisons-Alfort, France.
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MeSH Terms
Child, Preschool
Consumer Product Safety
Dietary Supplements / adverse effects,  standards*
Food, Fortified / adverse effects,  standards*
Middle Aged
Minerals / administration & dosage*,  adverse effects
Risk Assessment
Vitamins / administration & dosage*,  adverse effects
Young Adult
Reg. No./Substance:
0/Minerals; 0/Vitamins

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