| Comparison of different doses of remifentanil on the cardiovascular response to laryngoscopy and tracheal intubation. | |
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MedLine Citation:
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PMID: 10740557 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have compared three bolus and infusion regimens of remifentanil on the cardiovascular response to laryngoscopy and orotracheal intubation in three groups of 20 ASA I-II female patients, in a randomized, double-blind study. Patients in group 1 received glycopyrolate 200 micrograms i.v. followed by a bolus dose of remifentanil 1 microgram kg-1 over 30 s and an infusion of remifentanil at a rate of 0.5 microgram kg-1 min-1. The other patients received remifentanil 0.5 microgram kg-1 over 30 s and an infusion of 0.25 microgram kg-1 min-1 with (group 2) or without (group 3) pretreatment with glycopyrrolate 200 micrograms. All patients then received a sleep dose of propofol, rocuronium 0.6 mg kg-1 and 1% isoflurane with 67% nitrous oxide in oxygen. Laryngoscopy and tracheal intubation were performed 3 min later. Heart rate and arterial pressure were recorded at 1-min intervals from before induction of anaesthesia until 5 min after intubation. Baseline heart rate was similar in all groups, but decreased in group 3 (no glycopyrrolate) after induction and remained significantly lower after intubation compared with the other groups (P < 0.05). Heart rate and arterial pressure increased slightly after intubation in each group but there were no significant differences in mean arterial pressure between groups at any time. The incidence of bradycardia (one patient in group 2) and hypotension (two patients in groups 1 and 2 and three patients in group 3) was low. |
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Authors:
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A P Hall; J P Thompson; N A Leslie; A J Fox; N Kumar; D J Rowbotham |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: British journal of anaesthesia Volume: 84 ISSN: 0007-0912 ISO Abbreviation: Br J Anaesth Publication Date: 2000 Jan |
Date Detail:
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Created Date: 2000-04-07 Completed Date: 2000-04-07 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372541 Medline TA: Br J Anaesth Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 100-2 Citation Subset: IM |
Affiliation:
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University Department of Anaesthesia and Pain Management, Leicester Royal Infirmary, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analgesics, Opioid / administration & dosage*, pharmacology Blood Pressure / drug effects Dose-Response Relationship, Drug Double-Blind Method Female Heart Rate / drug effects Hemodynamics / drug effects* Humans Intubation, Intratracheal* Laryngoscopy* Middle Aged Piperidines / administration & dosage*, pharmacology Premedication |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Opioid; 0/Piperidines; 132875-61-7/remifentanil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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