Document Detail

Comparison of the different characteristics of sensed reflux events among different heartburn groups.
MedLine Citation:
PMID:  18797407     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIM: Presently, there are no studies comparing sensed acid reflux event (SARE) characteristics among different heartburn groups. Our aim was to compare the different esophageal acid reflux characteristics of an SARE among the different heartburn groups. METHODS: Patients with heartburn underwent endoscopy and pH testing and were stratified into 3 groups: erosive esophagitis (EE), nonerosive reflux disease (NERD), and functional heartburn (FH). Patients underwent esophageal pH testing using a 4-sensor pH probe, with the most distal pH sensor positioned 1 cm> lower esophageal sphincter (LES). RESULTS: Twenty-two patients had EE, 15 NERD, and 13 FH (M/F: 20/2, 12/3, 5/8, mean age: 51.5+/-3.7, 50.1+/-4.2, 50.3+/-3.8, respectively). The percentage of SAREs at 1 cm>LES that had reached 16 cm>LES was significantly higher in the FH group compared with NERD and EE (P<0.05). EE demonstrated the lowest nadir during an SARE and NERD the most acid reflux events before an SARE (up to 4 h). CONCLUSIONS: Patients with FH demonstrated the most SAREs that reached the proximal esophagus. EE patients demonstrated the lowest nadir pH during an SARE and NERD patients the most acid reflux events before an SARE, as compared with the other heartburn groups.
Ron Schey; Michael Shapiro; Tomas Navarro-Rodriguez; Shira S Fass; Bing Han; Christopher Wendel; Ronnie Fass
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical gastroenterology     Volume:  43     ISSN:  1539-2031     ISO Abbreviation:  J. Clin. Gastroenterol.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-20     Completed Date:  2009-11-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7910017     Medline TA:  J Clin Gastroenterol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  699-704     Citation Subset:  IM    
Section of Gastroenterology, Department of Medicine, The Neuroenteric Clinical Research Group, Southern Arizona VA Health Care, Tucson, AZ, USA.
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MeSH Terms
Esophageal pH Monitoring
Esophagitis / physiopathology*
Esophagus / physiopathology
Gastroesophageal Reflux / physiopathology*
Heartburn / physiopathology*
Middle Aged
Severity of Illness Index

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