Document Detail

Comparison of demographic and clinical characteristics of patients with early vs. adult vs. late onset ulcerative colitis.
MedLine Citation:
PMID:  23318090     Owner:  NLM     Status:  MEDLINE    
BACKGROUND & AIMS: There is limited data comparing influence of age on the presentation, clinical course, and therapeutic response of patients with ulcerative colitis. We aimed to compare the demographic and clinical characteristics of patients diagnosed with UC in older age vs. adulthood vs. early age.
METHODS: Five-hundred sixty one patients with UC seen at our center from 1995 to 2011 were categorized into early onset (EO), adult onset (AO) and late onset (LO) due to age at date of initial diagnosis. Patients diagnosed younger than age 17 were defined as EO, while those diagnosed between 17 and 60 were defined as AO and older than age 60 as LO. All patients were analyzed for demographic and clinical characteristics.
RESULTS: There was a male predominancy among LO patients (50% vs. 57.7% vs. 78.6%, p=0.004). Patients with EO UC were more likely to be non-smokers (p<0.001), and had higher family history of UC (p=0.02). Patients with EO UC had more steroid use (p=0.03), total colectomy (p=0.04), presence of chronic active disease (p=0.04) rates when compared with AO and LO groups. Patients in EO group had higher overall probability of surgery in 1, 5 and 10 years, when compared with patients in LO group (p=0.02), but it wasn't different between EO and AO groups (p=0.09).
CONCLUSIONS: Our study showed that clinical course of UC was more aggressive in younger ages. Also the difference between the demographic characteristics suggests that different age groups have different risk factors for the disease development.
Ismail Hakkı Kalkan; Ulkü Dağli; Erkin Oztaş; Bilge Tunç; Aysel Ulker
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2013-01-12
Journal Detail:
Title:  European journal of internal medicine     Volume:  24     ISSN:  1879-0828     ISO Abbreviation:  Eur. J. Intern. Med.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-07     Completed Date:  2013-09-13     Revised Date:  2014-03-28    
Medline Journal Info:
Nlm Unique ID:  9003220     Medline TA:  Eur J Intern Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  273-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
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MeSH Terms
Age of Onset
Colectomy / methods,  statistics & numerical data*
Colitis, Ulcerative* / diagnosis,  epidemiology,  physiopathology,  therapy
Glucocorticoids / therapeutic use*
Middle Aged
Patient Acuity
Risk Factors
Sex Factors
Survival Rate
Symptom Assessment* / methods,  statistics & numerical data
Turkey / epidemiology
Reg. No./Substance:
Comment In:
Eur J Intern Med. 2014 Feb;25(2):e19   [PMID:  23809429 ]

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