Document Detail

Comparison of delayed-release 5-aminosalicylic acid (mesalazine) and sulfasalazine as maintenance treatment for patients with ulcerative colitis.
MedLine Citation:
PMID:  2896139     Owner:  NLM     Status:  MEDLINE    
To assess the safety and efficacy of delayed-release mesalazine (5-aminosalicylic acid) as maintenance treatment for patients with ulcerative colitis, 100 patients with quiescent colitis were randomly grouped to receive either delayed-release mesalazine or an equivalent dose of enteric-coated sulfasalazine in a 48-wk trial. Groups were comparable for age, sex, and duration and extent of disease. Relapse rates at 48 wk were as follows: sulfasalazine 38.6% (95% confidence limits, 24%-54%) and mesalazine 37.5% (95% confidence limits, 24%-53%), chi 2 = 0.01, p greater than 0.90. Mean time to relapse, cumulative relapse rate, and relapse severity were similar in the two groups. Headaches and upper gastrointestinal symptoms--common at trial entry--improved to a greater extent in patients receiving mesalazine. Delayed-release mesalazine is an effective treatment for maintaining ulcerative colitis remission and is associated with fewer side effects than equivalent doses of enteric-coated sulfasalazine.
S A Riley; V Mani; M J Goodman; M E Herd; S Dutt; L A Turnberg
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gastroenterology     Volume:  94     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1988 Jun 
Date Detail:
Created Date:  1988-06-09     Completed Date:  1988-06-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1383-9     Citation Subset:  AIM; IM    
Department of Medicine, University of Manchester Medical School, Hope Hospital, Salford, United Kingdom.
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MeSH Terms
Aminosalicylic Acids / administration & dosage*,  adverse effects
Colitis, Ulcerative / drug therapy*
Delayed-Action Preparations
Middle Aged
Sulfasalazine / administration & dosage*,  adverse effects
Tablets, Enteric-Coated
Reg. No./Substance:
0/Aminosalicylic Acids; 0/Delayed-Action Preparations; 0/Tablets, Enteric-Coated; 599-79-1/Sulfasalazine; 89-57-6/Mesalamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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