Document Detail


Comparison of daily anti-hypertensive effects of amlodipine and nifedipine coat-core using ambulatory blood pressure monitoring - utility of "hypobaric curve" and "hypobaric area".
MedLine Citation:
PMID:  21699449     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Abstract When selecting anti-hypertensives, most physicians do not consider daily blood pressure (BP) variation. To evaluate the effectiveness of anti-hypertensives on the temporal profile of BP, we proposed three new parameters obtained by ambulatory BP monitoring and evaluated these parameters by comparing 5 mg of amlodipine and 40 mg of nifedipine coat-core. Hypobaric values were determined by subtracting BP data collected before administration of the drug from those collected after drug treatment at the corresponding time of day. The hypobaric curve was drawn by plotting the hypobaric values in chronological order, with the time at which the drug was taken set as the starting point. The hypobaric area was the area encircled between the 0 mmHg level line and the hypobaric curve. For amlodipine, the hypobaric areas of systolic blood pressure (SBP) and diastolic blood pressure (DBP) were -19,110 mmHg/min and -10,695 mmHg/min, respectively. Systolic BP decreased -13.3 mmHg, and DBP BP -7.4 mmHg as daily averages. For nifedipine coat-core, the hypobaric areas of SBP and DBP were -32,235 mmHg/min and -18,150 mmHg/min, respectively. Systolic BP decreased -22.3 mmHg and DBP -12.6 mmHg as daily averages. From the hypobaric curves, the trough-to-peak ratios of amlodipine and nifedipine coat-core were measured as 0.67 and 0.60, respectively. The total anti-hypertensive power of nifedipine coat-core, measured by the hypobaric area, was 1.69 times more potent than that of amlodipine. These parameters seem to be useful for evaluating the daily temporal profile of the BP-lowering effects of anti-hypertensive drugs.
Authors:
Keisuke Kuga; Dong Zhu Xu; Morio Ohtsuka; Kazutaka Aonuma; Alan H C Lau; Yoshihiko Watanabe; Kuniaki Ohtsuka
Related Documents :
11055169 - Effect of cast and noncast foot orthoses on plantar pressure and force during normal gait.
11475459 - Pneumatic bracing and total contact casting have equivocal effects on plantar pressure ...
10412439 - Load sharing between solid and fluid phases in articular cartilage: i--experimental det...
9453089 - Calibration problems encountered while monitoring stump/socket interface pressures with...
21298579 - Metabolic syndrome and heart failure-the risk, paradox, and treatment.
19361899 - A rotating inlay decreases contact pressure on inlay post after posterior cruciate subs...
4068069 - Experimental bacteroides fragilis bacteremia in a primate model: evidence that bacteroi...
7000459 - The baroreceptor reflexes in experimental hypertension.
21320189 - A systematic review of variability and reliability of manual and automated blood pressu...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental hypertension (New York, N.Y. : 1993)     Volume:  33     ISSN:  1525-6006     ISO Abbreviation:  Clin. Exp. Hypertens.     Publication Date:  2011  
Date Detail:
Created Date:  2011-06-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9305929     Medline TA:  Clin Exp Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  231-9     Citation Subset:  IM    
Affiliation:
Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba , Tsukuba, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Role of Angiotensin-(1-7) in Rostral Ventrolateral Medulla in Blood Pressure Regulation via Sympathe...
Next Document:  Calorie Restriction inhibits Sympathetic Nerve Activity via Anti-Oxidant Effect in the Rostral Ventr...