| Comparison of cytotoxin cytK promoters from Bacillus cereus strain ATCC 14579 and from a B. cereus food-poisoning strain. | |
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MedLine Citation:
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PMID: 15289566 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cytotoxin CytK produced by Bacillus cereus is believed to be involved in food-borne diseases. The transcriptional activity of the cytK promoter region in a food-poisoning strain was studied using a reporter gene and compared with that in the reference B. cereus strain ATCC 14579. In the food-poisoning strain, cytK is more strongly transcribed, possibly explaining the pathogenicity. The global regulator PlcR in B. cereus controls several putative virulence factors. It was found that PlcR regulates cytK in this clinical strain despite a mismatch in the PlcR recognition site, as currently defined. This suggests that the PlcR box consensus should be reconsidered and that the PlcR regulon might be larger than suspected. It is also shown that the high level of cytK transcription is not caused by a modification in the PlcR recognition site. |
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Authors:
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Julien Brillard; Didier Lereclus |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Microbiology (Reading, England) Volume: 150 ISSN: 1350-0872 ISO Abbreviation: Microbiology (Reading, Engl.) Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-08-03 Completed Date: 2004-10-05 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9430468 Medline TA: Microbiology Country: England |
Other Details:
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Languages: eng Pagination: 2699-705 Citation Subset: IM |
Affiliation:
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Institut Pasteur, Génétique et Physiologie des Bacillus Pathogènes, Département de Microbiologie Fondamentale et Médicale, 25 rue du Dr Roux, 75724 Paris cedex 15, France. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Bacillus cereus
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classification,
genetics*,
pathogenicity* Bacterial Proteins / genetics Bacterial Toxins / genetics* Base Sequence Cytotoxins / genetics* DNA, Bacterial / genetics Foodborne Diseases / microbiology Gene Expression Regulation, Bacterial Genes, Bacterial Genes, Reporter Kinetics Molecular Sequence Data Promoter Regions, Genetic RNA, Bacterial / genetics RNA, Messenger / genetics Sequence Homology, Nucleic Acid Trans-Activators / genetics Transcription, Genetic Virulence / genetics |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Proteins; 0/Bacterial Toxins; 0/Cytotoxins; 0/DNA, Bacterial; 0/PlcR protein, Bacillus; 0/RNA, Bacterial; 0/RNA, Messenger; 0/Trans-Activators |
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