Document Detail

Comparison of cytokine level in synovial fluid between successful and unsuccessful cases in arthrocentesis of the temporomandibular joint.
MedLine Citation:
PMID:  15015157     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The aim of this study was to compare proinflammatory cytokine levels between successful cases and unsuccessful cases of arthrocentesis in patients with internal derangement of the temporomandibular joint (TMJ). PATIENTS AND METHODS: This study involved 73 joints judged as successful and 30 judged as unsuccessful of 103 joints in 100 patients diagnosed with internal derangement of the TMJ and who underwent arthrocentesis. The diluted synovial fluid before undergoing arthrocentesis was aspirated from the superior joint space. The concentrations of interleukin (IL)-1beta, tumor necrosis factor-alpha, IL-6, and IL-8 were measured using an enzyme-linked immunosorbent assay. The differences in the detection rate and concentration of each cytokine between successful cases and unsuccessful cases were analyzed statistically. RESULTS: There was a statistically significant difference between successful cases (72.2%) and unsuccessful cases (95.5%) in the detection ratio of IL-6 (P <.05). There was a statistically significant difference between successful cases (0.017 pg/100 microg protein) and unsuccessful cases (0.046 pg/100 microg protein) in the concentration of IL-1beta (P <.05). CONCLUSION: It has been shown that the presence of IL-1beta and IL-6 in synovial fluid may be indicators of possible unsuccessful treatment following arthrocentesis for internal derangement of the TMJ.
Masaaki Nishimura; Natsuki Segami; Keiseki Kaneyama; Jun Sato; Kazumza Fujimura
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons     Volume:  62     ISSN:  0278-2391     ISO Abbreviation:  J. Oral Maxillofac. Surg.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-03-11     Completed Date:  2004-04-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8206428     Medline TA:  J Oral Maxillofac Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  284-7; discussion 287-8     Citation Subset:  AIM; D; IM    
Department of Oral and Maxillofacial Surgery, Kanazawa Medical University, Ishikawa, Japan.
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MeSH Terms
Chi-Square Distribution
Cytokines / analysis*
Dislocations / immunology,  therapy
Inflammation Mediators / analysis
Interleukin-1 / analysis
Interleukin-6 / analysis
Interleukin-8 / analysis
Middle Aged
Synovial Fluid / immunology*
Temporomandibular Joint Disorders / immunology,  therapy*
Treatment Outcome
Tumor Necrosis Factor-alpha / analysis
Reg. No./Substance:
0/Cytokines; 0/Inflammation Mediators; 0/Interleukin-1; 0/Interleukin-6; 0/Interleukin-8; 0/Tumor Necrosis Factor-alpha

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