Document Detail

Comparison of cyclizine and ondansetron for the prevention of postoperative nausea and vomiting in laparoscopic day-case gynaecological surgery.
MedLine Citation:
PMID:  11843745     Owner:  NLM     Status:  MEDLINE    
Seventy-four patients undergoing laparoscopic gynaecological surgery were randomly allocated to two groups receiving cyclizine 50 mg or ondansetron 4 mg at induction of anaesthesia. Anaesthetic and postoperative analgesia regimens were standardised. Approximately half of the patients in each group experienced some degree of postoperative nausea and vomiting (cyclizine, 56%; ondansetron, 54%). There was no difference between groups in respect of pre- and postdischarge incidence. Mean (SD) time to eye opening was significantly prolonged in the cyclizine group [10 (4) min vs. 8 (2) min; p < 0.001], but this had no influence on discharge times. Cyclizine and ondansetron appear equally effective in preventing postoperative nausea and vomiting but the 10-fold price differential favours cyclizine.
K Grimsehl; J B Whiteside; N Mackenzie
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anaesthesia     Volume:  57     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-02-14     Completed Date:  2002-02-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  England    
Other Details:
Languages:  eng     Pagination:  61-5     Citation Subset:  AIM; IM    
Anaesthetics, Ninewells Hospital, Dundee DD1 9SY, UK.
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MeSH Terms
Ambulatory Surgical Procedures
Anesthesia Recovery Period
Antiemetics / therapeutic use*
Cyclizine / therapeutic use*
Double-Blind Method
Histamine H1 Antagonists / therapeutic use
Ondansetron / therapeutic use*
Postoperative Nausea and Vomiting / prevention & control*
Serotonin Antagonists / therapeutic use
Reg. No./Substance:
0/Antiemetics; 0/Histamine H1 Antagonists; 0/Serotonin Antagonists; 82-92-8/Cyclizine; 99614-02-5/Ondansetron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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