Document Detail


Comparison of cutaneous leishmaniasis due to Leishmania (Viannia) braziliensis and L. (V.) guyanensis in Brazil: clinical findings and diagnostic approach.
MedLine Citation:
PMID:  11303265     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We compared the clinical findings and diagnostic methods for 66 patients with cutaneous leishmaniasis in the state of Bahia, Brazil, who were infected by Leishmania (Viannia) braziliensis (group A), with those for 68 patients in the state of Amazonas, Brazil, who were mainly infected by Leishmania (Viannia) guyanensis (group B). Differences were observed with regard to number, size, and location of skin lesions and to the pattern of lymphatic involvement. Patients in group B had smaller and more numerous lesions, which were frequently located above the waist, versus the larger but less numerous lesions among patients in group A, which were usually located on the lower limbs. Lymphatic involvement was present in 55 (83.3%) of the 66 patients in group A and in 42 (61.8%) of the 68 patients in group B (P=0.005). The positivity rates of imprints and skin culture procedures were higher in group B. Sensitivity of in vitro culture of skin aspirates was 47.0% and 91.2% for groups A and B, respectively (P<.001). Although hamster inoculation showed similar results in both groups, the interval before development of disease was shorter in group B. Our data provide substantial evidence that indicate that the disease caused by these species differs with regard to clinical presentation and diagnostic approach.
Authors:
G A Romero; M Vinitius De Farias Guerra; M Gomes Paes; V de Oliveira Macêdo
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2001-04-13
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  32     ISSN:  1058-4838     ISO Abbreviation:  Clin. Infect. Dis.     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-04-16     Completed Date:  2001-07-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1304-12     Citation Subset:  IM    
Affiliation:
Núcleo de Medicina Tropical, Universidade de Brasília, Brasília, Brasil. gromero@unb.br
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Animals
Brazil
Child
Humans
Leishmania braziliensis / growth & development,  isolation & purification,  physiology*
Leishmania guyanensis / growth & development,  isolation & purification,  physiology*
Leishmaniasis, Cutaneous / diagnosis,  parasitology*,  physiopathology
Middle Aged

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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