Document Detail


Comparison of continuous breath test and gastric scintigraphy for the measurement of gastric emptying rate in healthy and dyspeptic individuals.
MedLine Citation:
PMID:  23354159     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVE: To determine normative gastric emptying rates for the continuous breath test and to compare its findings with gastric scintigraphy in healthy volunteers and dyspeptic patients.
METHODS: A standard 250 kcal meal double-labeled with 1 mCi Tc colloid and 100 μg nonradioactive C-octanoic acid was administered to 20 healthy individuals and 22 dyspeptic patients attending a tertiary medical center in 2009-2010. Gastric emptying rate was measured simultaneously with sequential gastric scintigraphy and the continuous breath test. The results of the healthy controls were used as a normative reference. The findings of the two tests were analyzed by linear regression and κ statistics. In addition, the gastric half-emptying times (T ½) were compared by a κ test for evaluating the agreement of normal/abnormal results in both methods.
RESULTS: Background features were as follows: healthy individuals - 15 men/5 women, mean age 44.9±14 years and mean BMI 26.8±3.5; dyspeptic patients - 5 men/17 women, mean age 58.0±13 years and mean BMI 25.3±5.5. The upper limit of normal for gastric half-emptying time (T ½) was 140 min by the breath test. The linear correlation of T ½ between the methods was 0.64. The agreement of normal/abnormal T ½ between the methods was 0.65.
CONCLUSION: The continuous breath test may be a suitable method for the evaluation of gastric emptying. A larger study is required to determine its feasibility as the standard of care in dyspeptic patients.
Authors:
Ram Dickman; Tatyana Zilper; Adam Steinmetz; Lea Pakanaev; Yishai Ron; Hanna Bernstine; David Groshar; Yaron Niv; Haim Shirin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of gastroenterology & hepatology     Volume:  25     ISSN:  1473-5687     ISO Abbreviation:  Eur J Gastroenterol Hepatol     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-01-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9000874     Medline TA:  Eur J Gastroenterol Hepatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  291-5     Citation Subset:  IM    
Affiliation:
aDivision of Gastroenterology Departments of bNuclear Medicine cInternal Medicine A, Rabin Medical Center, Petah Tikva dDepartment of Gastroenterology & Hepatology, Sourasky Medical Center eSackler Faculty of Medicine, Tel Aviv University, Tel Aviv fGastroenterology Institute, Assaf Harofeh Medical Center, Tzrifin, Israel.
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