Document Detail

Comparison of coasting and intravenous albumin in the prevention of ovarian hyperstimulation syndrome.
MedLine Citation:
PMID:  12849806     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare the efficacy of coasting to prevent ovarian hyperstimulation syndrome (OHSS) with i.v. albumin and to determine if different timing of gonadotropin coasting would affect the IVF outcomes. DESIGN: Retrospective study. SETTING: University hospital-based IVF program. PATIENT(S): One hundred sixty-two women undergoing IVF treatment cycles who were considered to be at high risk for developing OHSS. INTERVENTION(S): Gonadotropin administration was withheld in 60 patients: either coasting occurred before follicular maturation (early coasting subset, n = 28) or follicular maturity was attained before coasting (late coasting subset, n = 32). Outcomes were compared in 102 patients at risk for OHSS who received i.v. albumin on the day of oocyte retrieval. MAIN OUTCOME MEASURE(S): Incidence of OHSS and outcome parameters. RESULT(S): Although the fertilization rates and the incidence of OHSS did not differ significantly between the coasting and i.v. albumin groups, the mean number of oocytes retrieved, the pregnancy rates, and implantation rates were significantly lower in the coasting group. There is no statistical difference in the entire outcome examined and the incidence of OHSS between the early and late coasting subsets. CONCLUSION(S): Coasting is as effective as i.v. albumin in preventing OHSS in high-risk patients but yields inferior pregnancy rates. Early coasting is as successful as late coasting in preventing OHSS with similar IVF outcome.
Chin-Der Chen; Kuang-Han Chao; Jehn-Hsiahn Yang; Shee-Uan Chen; Hong-Nerng Ho; Yu-Shih Yang
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Fertility and sterility     Volume:  80     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-07-09     Completed Date:  2003-08-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  86-90     Citation Subset:  IM    
Department of Obstetrics and Gynecology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
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MeSH Terms
Albumins / administration & dosage*
Chorionic Gonadotropin / administration & dosage,  pharmacology*
Estradiol / blood
Injections, Intravenous
Ovarian Hyperstimulation Syndrome / prevention & control*
Ovulation Induction / adverse effects,  methods*
Retrospective Studies
Sperm Injections, Intracytoplasmic / methods*
Time Factors
Reg. No./Substance:
0/Albumins; 0/Chorionic Gonadotropin; 50-28-2/Estradiol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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