| Comparison of coagulation factors and blood loss between O and non-O blood types following hydroxyethyl starch infusion. | |
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MedLine Citation:
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PMID: 20508790 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Individuals with type O blood are more likely to have reduced factor VIII and von Willebrand factor levels compared to their non-O counterparts. Hydroxyethyl starch (HES), which is widely used for blood volume replacement, can induce coagulopathy. Therefore, we tested whether blood type O patients show more coagulopathy and blood loss than non-O patients after infusion of 6% HES. METHODS: Thirty-four non-O and 20 type O patients scheduled for posterior lumbar interbody fusion (PLIF) involving 3 vertebrae or less from June 2007 to August 2008 were enrolled. Fifteen ml/kg of 6% HES was administered during the operation. Coagulation profiles was checked at pre-infusion (T0), 5 min after the end of infusion (T1), 3 hr after the end of infusion (T2), and 24 hr after the end of infusion (T3). Bleeding was measured during and after surgery for 24 hours. RESULTS: Baseline factor VIII concentration was lower and aPTT was longer in type O patients compared to those of non-O patients. 6% HES infusion decreased most of the coagulation factors at T1 in both groups, which were recovered in a time dependent manner. Factor VIII and aPTT of blood type O patients fell off the normal range at T1. However, other coagulation factors, thromboelastography variables, and blood loss were not different between the groups. CONCLUSIONS: Despite inborn low factor VIII which further decreased shortly after HES infusion, blood type O patients did not show more blood loss than non-O blood type after 15 ml/kg of HES infusion in PLIF surgery. |
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Authors:
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Soo Joo Choi; Hyun Joo Ahn; Jae Ik Lee |
Publication Detail:
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Type: Journal Article Date: 2010-04-28 |
Journal Detail:
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Title: Korean journal of anesthesiology Volume: 58 ISSN: 2005-7563 ISO Abbreviation: Korean J Anesthesiol Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-05-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101502451 Medline TA: Korean J Anesthesiol Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 344-50 Citation Subset: - |
Affiliation:
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Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. |
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