Document Detail


Comparison of clonidine and epinephrine in lidocaine anaesthesia for lower third molar surgery.
MedLine Citation:
PMID:  16053850     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The admixture of clonidine or epinephrine to lidocaine for inferior alveolar nerve block was studied with regard to onset, duration, intensity of anaesthesia, postoperative analgesia, systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), ST segment depression > or =1 mm and cardiac arrhythmias. Forty healthy patients (ASA I) received 2 ml 2% lidocaine with clonidine (15 microg/ml; n = 20) or epinephrine (12.5 microg/ml; n = 20) in a double-blind fashion for lower third molar surgery. Duration and intensity were not different between groups, while onset was significantly different by subjective evaluation. The need for postoperative pain medication was significantly lower in the clonidine group. There was a significant decrease in SBP and MAP in both groups 35 min after administration of anaesthesia compared with basal values, while DBP was significantly lower only in the clonidine group. There was no significant difference in SBP, DBP and MAP between groups. HR was significantly increased in the epinephrine group 5 min after administration of anaesthesia and during surgery compared with the clonidine group and with basal values. The presented data suggest that clonidine could be a useful and safe alternative to epinephrine for intraoral block anaesthesia.
Authors:
B Brkovic; L Todorovic; D Stojic
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  International journal of oral and maxillofacial surgery     Volume:  34     ISSN:  0901-5027     ISO Abbreviation:  Int J Oral Maxillofac Surg     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-08-01     Completed Date:  2005-08-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8605826     Medline TA:  Int J Oral Maxillofac Surg     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  401-6     Citation Subset:  D; IM    
Affiliation:
Clinic of Oral Surgery, University of Belgrade, Serbia and Montenegro, 11070 Belgrade. marina-s@Eunet.yu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adrenergic alpha-Agonists / pharmacology*
Adult
Aged
Anesthesia, Dental / methods*
Anesthetics, Local / pharmacology
Blood Pressure / drug effects
Clonidine / pharmacology*
Double-Blind Method
Epinephrine / pharmacology
Female
Heart Rate / drug effects
Humans
Lidocaine / pharmacology
Male
Mandible
Middle Aged
Molar, Third / surgery*
Nerve Block
Pain, Postoperative / prevention & control
Tooth Extraction*
Vasoconstrictor Agents / pharmacology*
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Anesthetics, Local; 0/Vasoconstrictor Agents; 137-58-6/Lidocaine; 4205-90-7/Clonidine; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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