Document Detail

Comparison of the clinical performance, contraceptive efficacy and acceptability of levonorgestrel-releasing IUD and Norplant-2 implants in China.
MedLine Citation:
PMID:  2112079     Owner:  NLM     Status:  MEDLINE    
The levonorgestrel-releasing IUD (LNG-IUD, 20 micrograms/d) and the Norplant-2 implants were studied in a randomized comparative clinical trial with 200 women for one year. No pregnancy or expulsion occurred with the Norplant-2. In the LNG-IUD group, there was one pregnancy at the 12th month of use after an unnoticed expulsion. The net cumulative pregnancy and expulsion rates of LNG-IUD were 1.0 and 3.0. The removal rate due to menstrual disturbances in both LNG-IUD and Norplant-2 groups was 3.0. The use-related discontinuation rates were 9.0 and 3.0, and the continuation rates were 90.0 and 96.0, respectively. The differences were not statistically significant. Menstrual disturbance was the main side effect. It was improved after long time use, especially in the LNG-IUD group. After one year, the percentages of women with amenorrhea were 18.9 for the LNG-IUD and 8.3 for the Norplant-2. The menstrual blood loss was statistically significantly reduced in the LNG-IUD group, and blood haemoglobin concentration increased in both groups. The LNG-IUD and Norplant-2 are highly effective, safe, long-acting, and well accepted by the Chinese women.
J Gao; S L Wang; S C Wu; B L Sun; H Allonen; T Luukkainen
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Contraception     Volume:  41     ISSN:  0010-7824     ISO Abbreviation:  Contraception     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-07-11     Completed Date:  1990-07-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0234361     Medline TA:  Contraception     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  485-94     Citation Subset:  IM    
Department of Female Clinical Research of Fertility Regulation, National Research Institute for Family, Beijing, China.
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MeSH Terms
Administration, Intravaginal
Antithrombin III / analysis
Drug Implants / adverse effects,  therapeutic use
Hemoglobins / analysis
Intrauterine Devices, Medicated* / adverse effects
Menstruation / drug effects
Menstruation Disturbances / chemically induced
Norgestrel / pharmacology*
Plasminogen / analysis
alpha 1-Antitrypsin / analysis
Reg. No./Substance:
0/Drug Implants; 0/Hemoglobins; 0/alpha 1-Antitrypsin; 6533-00-2/Norgestrel; 797-63-7/Levonorgestrel; 9000-94-6/Antithrombin III; 9001-91-6/Plasminogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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