Document Detail

Comparison of the clinical outcomes between fresh blastocyst and vitrified-thawed blastocyst transfer.
MedLine Citation:
PMID:  23188411     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare the clinical outcomes between fresh and vitrified-thawed day 5 blastocyst transfers.
DESIGN: Retrospective case control study.
SETTING: Tertiary referral center.
PATIENT(S): Patients 38 years of age or less who underwent IVF/ICSI cycles with fresh or frozen-thawed blastocysts transferred from June 1, 2009 to November 30, 2011
INTERVENTION(S): Vitrification and thawing of day 5 blastocysts using the Cryotop method. (Kitazato BioPharma Co., Ltd., Fuji city, Shizuoka, Japan)
MAIN OUTCOME MEASURE(S): Clinical pregnancy rate, implantation rate, ongoing pregnancy rate, and multiple pregnancy rates.
RESULTS: Of the 118 cycles in the fresh transfer group, 234 blastocysts were transferred. The clinical pregnancy rate was 66.1 % and implantation rate was 50.9 %. The ongoing pregnancy rate was 56.8 % and the rates for singleton and twin pregnancies were 53.7 % and 44.8 %. Of the 59 cycles in the vitrified-thawed group, 111 blastocysts were transferred. The clinical pregnancy rate was 59.3 % and implantation rate was 43.2 %. The ongoing pregnancy rate was 47.5 % and the rates for singleton and twin pregnancies were 60.7 % and 39.3 %. The clinical pregnancy rate, implantation rate and ongoing pregnancy rate did not differ significantly between the two groups.
CONCLUSIONS: The implantation rates were not significantly different between the fresh and the vitrified-thawed groups. Thus, single embryo transfer may be considered in fresh cycles to decrease multiple pregnancy rates. The surplus embryos should be vitrified for the frozen embryo transfer to improve the cumulative pregnancy rate.
Pei-Yun Ku; Robert Kuo-Kuang Lee; Shyr-Yeu Lin; Ming-Huei Lin; Yuh-Ming Hwu
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2012-11-14
Journal Detail:
Title:  Journal of assisted reproduction and genetics     Volume:  29     ISSN:  1573-7330     ISO Abbreviation:  J. Assist. Reprod. Genet.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-24     Completed Date:  2013-07-12     Revised Date:  2013-12-04    
Medline Journal Info:
Nlm Unique ID:  9206495     Medline TA:  J Assist Reprod Genet     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1353-6     Citation Subset:  IM    
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MeSH Terms
Blastocyst* / cytology,  physiology
Case-Control Studies
Cryopreservation / methods
Embryo Implantation
Embryo Transfer / methods*
Fertilization in Vitro
Pregnancy Rate
Retrospective Studies
Single Embryo Transfer
Sperm Injections, Intracytoplasmic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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