Document Detail

Comparison of clinical outcome between histidine-triptophan-ketoglutalate solution and cold blood cardioplegic solution in mitral valve replacement.
MedLine Citation:
PMID:  9892485     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: This study was conducted to compare the effect of histidine-triptophan-ketoglutalate solution (HTK) with that of cold blood cardioplegic solution (CBC) in mitral valve surgery. METHOD: Forty-six patients who underwent mitral valve replacement between January 1994 and December 1996 were enrolled in this study. Twenty patients received HTK (HTK group), while 27 patients had CBC (CBC group) as myocardial protection. HTK was given as a single high dose, whereas CBC was used in the usual multidose format. RESULT: The doses of inotropic agent at the end of extracorporeal circulation did not differ between the HTK group and the CBC group. Creatine kinase values (units) on day 1 and day 2 were 1140+/-412, 921+/-436 for the HTK group and 904+/-335, 816+/-420 for the CBC group, respectively (p = NS). Spontaneous defibrillation occurred in 26% of the CBC group and 90% of the HTK group (p < 0.05). Pacing was temporarily used in 20% of the HTK group and 44% of the CBC group after extracorporeal circulation (p < 0.05). CONCLUSIONS: These results suggest that HTK provided more adequate myocardial protection in mitral valve surgery.
J Sakata; K Morishita; T Ito; T Koshino; T Kazui; T Abe
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of cardiac surgery     Volume:  13     ISSN:  0886-0440     ISO Abbreviation:  J Card Surg     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1999-03-25     Completed Date:  1999-03-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8908809     Medline TA:  J Card Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  43-7     Citation Subset:  IM    
Department of Thoracic and Cardiovascular Surgery, Sapporo Medical University School of Medicine, Hokkaido, Japan.
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MeSH Terms
Cardioplegic Solutions* / chemistry
Case-Control Studies
Glucose / physiology
Heart Valve Prosthesis Implantation*
Mannitol / analysis
Middle Aged
Mitral Valve
Myocardial Reperfusion Injury / prevention & control*
Potassium Channels / analysis,  metabolism
Potassium Chloride
Procaine / analysis
Treatment Outcome
Reg. No./Substance:
0/Bretschneider cardioplegic solution; 0/Cardioplegic Solutions; 0/Potassium Channels; 50-99-7/Glucose; 59-46-1/Procaine; 69-65-8/Mannitol; 7447-40-7/Potassium Chloride

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