Document Detail


Comparison of clinical information gained from routine blood-gas analysis and from gastric tonometry for intramural pH.
MedLine Citation:
PMID:  8093745     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The measurement of gastric intramucosal pH (pHi) has been advocated to assist in decision-making for critically ill patients. To assess whether the information obtained from the measurement of pHi can be obtained from other measurements of metabolic acidosis, we studied 20 consecutive patients admitted to the intensive care unit. A mean of eight (range two to fourteen) data sets per patient were obtained, comprising measurement of arterial pH, pO2, pCO2, and oxygen saturation, tonometer balloon fluid pCO2, arterial pressures, and cardiac output. Bicarbonate concentration, base deficit or excess in blood and extracellular fluid, and pHi were calculated from these measurements. Relations between the variables and pHi were assessed by within-subject correlation comparisons. There were significant correlations (r > 0.6, p < 0.001) between markers of metabolic acidosis (base deficit in blood and extracellular fluid and bicarbonate concentration) and pHi. A blood base deficit of -4.65 or less and an extracellular-fluid base deficit of -6.13 or less could estimate pHi below 7.32 (lower limit of normal range) with sensitivity of at least 77% and specificity of at least 96%. There was no patient in whom either pHi or blood base deficit consistently reflected acidosis when the other variable did not. We conclude that the information that is obtained by gastric tonometry for pHi can be obtained more simply from measurements of metabolic acidosis; these variables can be calculated from routinely available blood-gas measurements.
Authors:
O Boyd; C J Mackay; G Lamb; J M Bland; R M Grounds; E D Bennett
Related Documents :
9575965 - Interindividual variation in total and carrier-mediated lactate influx into red blood c...
3632535 - Anaerobic energetics of the simulated aerial combat maneuver (sacm).
24229095 - Onset of flow in a confined colloidal glass under an imposed shear stress.
24008675 - Effects of cyclic motion on coronary blood flow.
8481525 - Blood-feeding host preferences of the isomorphic species simulium venustum and s. trunc...
8428495 - Adequacy of gut oxygenation in endotoxemia and sepsis.
Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Lancet     Volume:  341     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-02-19     Completed Date:  1993-02-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  142-6     Citation Subset:  AIM; IM    
Affiliation:
General Intensive Care Unit, St George's Hospital, London, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acidosis / diagnosis*
Adolescent
Adult
Aged
Blood Gas Analysis*
Female
Gastric Acidity Determination*
Humans
Hydrogen-Ion Concentration
Male
Middle Aged
Comments/Corrections
Comment In:
Lancet. 1993 Mar 13;341(8846):692   [PMID:  8095595 ]
Lancet. 1993 Mar 13;341(8846):691-2   [PMID:  8095594 ]
Lancet. 1993 Mar 13;341(8846):692-3   [PMID:  8095596 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Frequency of clonal remission in acute myeloid leukaemia.
Next Document:  Balance of synovial fluid IL-1 beta and IL-1 receptor antagonist and recovery from Lyme arthritis.