| Comparison of clinical and imaging features in succinate dehydrogenase-positive versus sporadic paragangliomas. | |
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MedLine Citation:
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PMID: 22136839 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Limited data exist concerning the clinical and imaging features that distinguish sporadic from familial paragangliomas (PGLs). METHODS: Clinical, genetic (succinate dehydrogenase [SDHB] vs no SDHx), and imaging (computed tomography [CT], magnetic resonance imaging, (18)F-fluoro-deoxy-glucose positron emission tomography [(18)F-FDG-PET]) features obtained during a decade in 124 PGL patients were studied. Data were analyzed by Fisher's exact test or Wilcoxon rank-sum test. RESULTS: Mean age at diagnosis was younger in the SDHB-positive (SDHB+) group compared with the sporadic (no SDHx) group (28 vs 39 years, respectively, P < .001). Rate of supradiaphragmatic neoplasms were greater in the SDHB+ group (16.7 vs 4.7%, P = .11). Metastasis rates were greater in the SDHB+ group (78.9 vs 48.3%, P < .001), as was the existence of metastases or multiple PGLs at presentation (38.5 vs 16.7%, P < .05). Tumor volumes >250 mL were exclusively observed in SDHB+ patients (P < .05). On CT, SDHB+ tumors were more enhanced (P < .05). On (18)F-FDG-PET, SDHB+ tumors' had greater mean standard uptake values (12.3 vs 8.0, P < .05). CONCLUSION: Clinically young age, large tumor volume, greater rate of metastatic and multifocal PGLs, greater SUV values on (18)F-FDG-PET, and increased CT enhancement are observed in SDHB+ PGLs. These findings may warrant genetic screening. Because SDHB+ patients demonstrate more supradiaphragmatic lesions, whole-body imaging may be of particular value in these patients. |
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Authors:
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Aradhana M Venkatesan; Hari Trivedi; Karen T Adams; Electron Kebebew; Karel Pacak; Marybeth S Hughes |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Surgery Volume: 150 ISSN: 1532-7361 ISO Abbreviation: Surgery Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0417347 Medline TA: Surgery Country: United States |
Other Details:
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Languages: eng Pagination: 1186-93 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2011. Published by Mosby, Inc. |
Affiliation:
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Center for Interventional Oncology, Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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