Document Detail

Comparison of clinical effects of propranolol (Inderal) with once daily slow-release oxprenolol (Slow Trasicor) in angina pectoris.
MedLine Citation:
PMID:  378729     Owner:  NLM     Status:  MEDLINE    
In a double-blind, crossover, randomized study, the therapeutic effectiveness of a single daily dose of slow-release oxprenolol (160 mg/day) was compared with a conventional dosage schedule of propranolol (40 mg three times daily) in eighteen patients with uncomplicated, stable exercise-induced angina pectoris. Compared to control values both drugs produced equipotent reduction in the frequency and severity of anginal attacks accompanied by a significant increase in exercise tolerance, a significant suppression of exercising heart rate and an appreciable reduction in the electrocardiographic evidence of myocardial ischaemia when tested on a treadmill. The possible advantages offered by a single dose treatment with slow-release oxprenolol are discussed.
P A Majid; P J de Feijter; R Wardeh; E E van der Wall; J P Roos
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The Journal of international medical research     Volume:  7     ISSN:  0300-0605     ISO Abbreviation:  J. Int. Med. Res.     Publication Date:  1979  
Date Detail:
Created Date:  1979-09-25     Completed Date:  1979-09-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0346411     Medline TA:  J Int Med Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  194-200     Citation Subset:  IM    
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MeSH Terms
Angina Pectoris / drug therapy*
Blood Pressure / drug effects
Clinical Trials as Topic
Delayed-Action Preparations
Double-Blind Method
Exercise Test
Heart Rate / drug effects
Middle Aged
Oxprenolol / administration & dosage,  therapeutic use*
Propranolol / administration & dosage,  therapeutic use*
Reg. No./Substance:
0/Delayed-Action Preparations; 525-66-6/Propranolol; 6452-71-7/Oxprenolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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