Document Detail

Comparison of clinical characteristics of combined hepatocellular-cholangiocarcinoma and other primary liver cancers.
MedLine Citation:
PMID:  23034166     Owner:  NLM     Status:  Publisher    
BACKGROUND AND AIM: Combined hepatocellular-cholangiocarcinoma (CHC) is a rare liver malignancy. In this study, we compared patient characteristics and outcomes for primary CHC, intrahepatic cholangiocarcinoma (ICC), and hepatocellular carcinoma (HCC). METHODS: Medical records of patients with tissue-proven CHC (65 cases) treated at the Chang Gung Memorial Hospital between 1991 and 2005 were retrospectively reviewed. These records were compared to records of patients diagnosed with tissue-proven HCC (1985 cases) and ICC (127 cases) during the same period. RESULTS: Hepatitis B and C are major causes of CHC. CHC patients exhibited greater similarity to HCC than to ICC patients with respect to cirrhotic changes, age, and positive serology for HBsAg and anti-hepatitis C antibody. Survival was related to tumor characteristics and intervention therapies, but not to etiologies. CONCLUSIONS: The clinical characteristics of CHC are similar to those of HCC, but overall survival is more similar to that of ICC; survival may be related to tumor biology rather than the cause. Multimodal treatment with an initial aggressive therapeutic approach can improve survival.
Chern-Horng Lee; Sen-Yung Hsieh; Chee-Jen Chang; Yu-Jr Lin
Related Documents :
16289716 - Hyperthermic isolated limb perfusion (hilp) in malignant melanoma. experience with 101 ...
23744856 - High-grade gi lymphoma presenting with diarrhoea.
11044186 - Classical chemotherapy for metastatic melanoma.
9306586 - Technique and results of regional hyperthermic cytostatic arm perfusion for malignant m...
19628566 - Aib1 is a predictive factor for tamoxifen response in premenopausal women.
22948836 - Improved long-term survival after major resection for hepatocellular carcinoma: a multi...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-4
Journal Detail:
Title:  Journal of gastroenterology and hepatology     Volume:  -     ISSN:  1440-1746     ISO Abbreviation:  J. Gastroenterol. Hepatol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607909     Medline TA:  J Gastroenterol Hepatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd.
Division of General Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The International Code of Marketing of Breast-milk Substitutes: lessons learned and implications for...
Next Document:  Elevated levels of anti inflammatory IL-10 and pro inflammatory IL-17 in malignant pleural effusions...