| Comparison of clastogenic effects of antimony and bismuth as trioxides on mice in vivo. | |
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MedLine Citation:
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PMID: 7688540 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Comparison of the clastogenic effects of antimony and bismuth used as trioxides, when administered orally by gavaging to laboratory bred male mice, showed that the former was more strongly clastogenic than the latter. Three doses of each chemical (400, 666.67, and 1000 mg/kg body wt), corresponding to 1/50, 1/30, and 1/20 of oral LD50 of antimony trioxide, were fed daily to sets of mice up to 21 d. Animals were sacrificed on day 7, 14, and 21 of the experiment. Chromosomal aberrations and mitotic index were studied from bone marrow cells following a colchicine-air drying Giemsa schedule. The frequencies of chromosomal aberrations induced by both chemicals were directly proportional to the dose used and the duration of exposure, indicating their cumulative effects on the organism. The highest dose of antimony, given for the longest period was, however, lethal. Effects on germ cells, as shown by screening for sperm head abnormalities, were not significant. |
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Authors:
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N Gurnani; A Sharma; G Talukder |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biological trace element research Volume: 37 ISSN: 0163-4984 ISO Abbreviation: Biol Trace Elem Res Publication Date: 1993 May-Jun |
Date Detail:
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Created Date: 1993-09-14 Completed Date: 1993-09-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7911509 Medline TA: Biol Trace Elem Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 281-92 Citation Subset: IM |
Affiliation:
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Department of Botany, University of Calcutta. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antimony / toxicity* Bismuth / toxicity* Chromosome Aberrations* Male Mice Mutagens / toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Mutagens; 1304-76-3/bismuth oxide; 1309-64-4/antimony trioxide; 7440-36-0/Antimony; 7440-69-9/Bismuth |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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