Document Detail


Comparison of chlorpromazine versus morphine hydrochloride for treatment of neonatal abstinence syndrome.
MedLine Citation:
PMID:  18644009     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To compare the duration of treatment for neonatal abstinence syndrome (NAS) using chlorpromazine versus morphine hydrochloride. METHODS: We compared two case series of term infants with NAS treated with either morphine hydrochloride (MH) or chlorpromazine (CP). Seventeen infants were treated with MH from 1998 to 1999, and 20 infants were managed with CP from 2000 to 2001. The duration of treatment was compared, and multivariate analysis was used to identify independent risk factors related to the duration of treatment. RESULTS: Characteristics of the mothers (duration of drug addiction, abuse of other substances) and infants (birth weight, proportion breastfed) were similar in the two groups. The mean duration of CP treatment was 6 days (range 3.5-9 days), significantly fewer days than with MH treatment, which was 16 days (range 10-21 days; p < 0.001). There were fewer hospitalization days (11 days; range 9-14 days) for CP treatment compared with MH-treated infants (18 days; range 16-25 days). Treatment with CP was independently associated with shorter hospitalization time. CONCLUSION: CP appears to shorten the duration of NAS compared with MH. Larger prospective randomized trials are needed to confirm our findings.
Authors:
E Mazurier; G Cambonie; E Barbotte; A Grare; V Pinzani; J C Picaud
Related Documents :
8283359 - Effect of dexamethasone on protein metabolism in infants with bronchopulmonary dysplasia.
24447469 - First versus second stage c/s maternal and neonatal morbidity: a systematic review and ...
3528049 - Treatment of congenital immune deficiencies with a thymic hormone--thymic humoral factor.
24351689 - Mothers' reports on systemic signs and symptoms associated with teething.
11882079 - Use of protein-a column and porcine factor viii.
21572929 - Looking across domains to understand infant representation of emotion.
12762429 - Antenatal and intrapartum risk factors for birth asphyxia among emergency obstetric ref...
17903309 - Bench-to-bedside review: developmental influences on the mechanisms, treatment and outc...
6197019 - Perinatal mortality--report of a hospital based study.
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2008-07-16
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  97     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-10     Completed Date:  2009-01-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  1358-61     Citation Subset:  IM    
Affiliation:
CHU de Montpellier, Service neonatologie, Hopital Arnaud De Villeneuve, Montpellier, France. e-mazurier@chu-montpellier.fr
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Antiemetics / therapeutic use*
Chlorpromazine / therapeutic use*
Dopamine Antagonists / therapeutic use*
Female
Humans
Infant, Newborn
Male
Morphine / therapeutic use*
Narcotic Antagonists / therapeutic use*
Neonatal Abstinence Syndrome / drug therapy*,  therapy
Severity of Illness Index
Substance Withdrawal Syndrome / etiology
Time Factors
Chemical
Reg. No./Substance:
0/Antiemetics; 0/Dopamine Antagonists; 0/Narcotic Antagonists; 50-53-3/Chlorpromazine; 57-27-2/Morphine
Comments/Corrections
Comment In:
Acta Paediatr. 2008 Oct;97(10):1321-3   [PMID:  18681891 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Neuroimaging genetics: new perspectives in research on major depression?
Next Document:  Clinical trial: the incidence and early mortality after peptic ulcer perforation, and the use of low...