Document Detail


Comparison of chlormethiazole (Heminevrin) and chlordiazepoxide (Librium) in the treatment of acute alcohol withdrawal.
MedLine Citation:
PMID:  6674819     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was carried out to compare the efficacy of chlormethiazole and chlordiazepoxide in the treatment of acute alcohol withdrawal syndrome in 40 patients. Repeated biochemical, clinical, and psychophysiological measurements were obtained in a randomized, double-blind design in which one group of patients received chlormethiazole and a second group received chlordiazepoxide over a period of 7 days. Analysis indicated both drugs to be of equivalent potency and were equally well tolerated by patients. The more severe aspects of withdrawal were brought under control within the first 4 days of treatment. However, even at 7 days, there still persisted some symptoms attributable to the withdrawal from alcohol.
Authors:
Y D Lapierre; D R Bulmer; L K Oyewumi; M L Mauguin; V J Knott
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Neuropsychobiology     Volume:  10     ISSN:  0302-282X     ISO Abbreviation:  Neuropsychobiology     Publication Date:  1983  
Date Detail:
Created Date:  1984-06-20     Completed Date:  1984-06-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7512895     Medline TA:  Neuropsychobiology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  127-30     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Alcohol Withdrawal Delirium / drug therapy*
Alcoholism / rehabilitation*
Chlordiazepoxide / adverse effects,  therapeutic use*
Chlormethiazole / adverse effects,  therapeutic use*
Double-Blind Method
Female
Humans
Male
Middle Aged
Psychoses, Alcoholic / drug therapy*
Chemical
Reg. No./Substance:
533-45-9/Chlormethiazole; 58-25-3/Chlordiazepoxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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