Document Detail


Comparison of chemically induced and spontaneous murine thymic lymphomas in RF and AKR mice: differential expression of c-myc and c-myb.
MedLine Citation:
PMID:  3855567     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Expression of 11 cellular oncogenes was determined in normal vs. lymphomatous thymic tissues of RF and AKR mice; only c-myc and c-myb transcripts were detected in an age-inappropriate pattern in thymomas. Normal thymocytes from young RF mice contained RNA transcripts of both genes, but the transcripts were no longer detected at 9 or more weeks of age. More than 90% of RF thymomas, occurring at 20-28 weeks of age after skin painting with 3-methylcholanthrene at 12 weeks, contained c-myc transcripts, and 70% of the tumors contained c-myb transcripts. Seven cell lines derived from these 3-methylcholanthrene thymomas expressed both cellular genes, as did 2 rare spontaneous thymomas of 12-month-old RF mice. No indication of rearrangement or amplification of either gene was seen in any of the RF tumors or cell lines. In AKR mice, transcripts of the 2 genes persisted longer in the normal thymus than in RF mice, but they were no longer detected at 26 weeks of age. Of 3 thymomas in 6-month-old 3-methylcholanthrene-treated AKR mice, all expressed c-myb and 2 expressed c-myc. Among 11 spontaneous AKR thymomas, however, only 2 showed detectable levels of both genes, and 2 more expressed c-myc or c-myb but not both.
Authors:
J Chinsky; F Lilly; G Childs
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  82     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1985 Jan 
Date Detail:
Created Date:  1985-03-01     Completed Date:  1985-03-01     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  565-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
DNA / analysis
DNA, Neoplasm / analysis
Female
Gene Expression Regulation*
Lymphoma / chemically induced,  genetics*
Mice
Mice, Inbred AKR
Mice, Inbred Strains
Oncogenes*
Thymoma / chemically induced,  genetics*
Thymus Gland / analysis
Thymus Neoplasms / chemically induced,  genetics*
Grant Support
ID/Acronym/Agency:
P01CA31855/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/DNA, Neoplasm; 9007-49-2/DNA
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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