Document Detail


Comparison of changes in markers of muscle damage induced by eccentric exercise and ischemia/reperfusion.
MedLine Citation:
PMID:  19804580     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
To examine the effects of eccentric exercise (EE) and ischemia/reperfusion (I/R) on the markers of muscle damage, 72 rats were randomly assigned to the EE group, I/R group and control group (C), respectively. The rats in EE ran downhill on a treadmill with a 16 ° inclination at a constant speed for 90 min, and the rats in the I/R group underwent 90 min of four-limb ischemia, followed by 24, 48 and 72 h of reperfusion. Blood and tissue samples were collected immediately, 24, 48 and 72 h after exercise or reperfusion. Quantitative analyses showed that the I/R group had a significantly larger mitochondrial volume at 24 h after reperfusion compared with the C, and there were more disrupted Z-lines in the EE group and more disrupted mitochondria in the I/R group at 24 h after exercise or reperfusion. When compared with the C, a significantly lower total antioxidant capacity and higher interleukin-6 value were observed after exercise or reperfusion. Our data suggest that although EE and I/R result in some similar changes in the muscle damage markers, there are still some differences. The EE- and I/R-induced muscle damage may be due to different mechanisms.
Authors:
Q-S Su; J-G Zhang; R Dong; B Hua; J-Z Sun
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of medicine & science in sports     Volume:  20     ISSN:  1600-0838     ISO Abbreviation:  Scand J Med Sci Sports     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-11-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111504     Medline TA:  Scand J Med Sci Sports     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  748-56     Citation Subset:  IM    
Copyright Information:
© 2009 John Wiley & Sons A/S.
Affiliation:
Faculty of Sports Medicine, Chengdu Sports University, Chengdu, China.
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