| Comparison of changes in lipid profile after bilio-intestinal bypass and gastric banding in patients with morbid obesity. | |
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MedLine Citation:
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PMID: 15826472 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The presence of hypercholesterolemia is currently not considered a selection criteria for performing gastric restrictive or diversionary bariatric surgery. METHODS: We prospectively investigated the effects of the bilio-intestinal bypass (BI-bypass) with a wide cholecysto-jejunal anastomosis and of adjustable gastric banding (AGB) on blood lipid concentrations in obese patients. To clarify the mechanism of the hypocholesterolemic effect of the BI-bypass, daily fecal sterol excretion was measured by gas-liquid chromatography (GLC). RESULTS: At 1 year after BI-bypass compared to baseline, the hypercholesterolemic (n=18) and the normocholesterolemic (n=19) patients significantly reduced total (-38% and -27%, respectively), LDL (-47% and -24%, respectively) and HDL (-11% and -13%, respectively) cholesterol and total / HDL cholesterol ratio (-25% and -13%, respectively). At 1 year after AGB, the total / HDL cholesterol ratio was significantly decreased (-11%) compared to baseline in hypercholesterolemic (n=12) but not in normocholesterolemic (n=6) patients, while total and LDL cholesterol were not affected in both groups. At 3 years after BI-bypass compared to baseline, the hypercholesterolemic (n=9) and the normocholesterolemic (n=11) patients significantly reduced total (-43% and -28%, respectively) and LDL (-53% and -29%, respectively) cholesterol and total / HDL cholesterol ratio (-38% and -21%, respectively). The BI-bypass induced a significant (P <0.005; n=7) 6-fold increase in mean fecal cholesterol output. CONCLUSIONS: The BI-bypass but not the AGB leads to a persistent and marked beneficial effect on blood LDL cholesterol associated with an increased cholesterol fecal output. BI-bypass but not AGB is indicated in morbidly obese patients with hypercholesterolemia. |
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Authors:
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Stefano Ginanni Corradini; Annarita Eramo; Carla Lubrano; Giovanni Spera; Alessandra Cornoldi; Antonio Grossi; Francesca Liguori; Maria Siciliano; Massimo Codacci Pisanelli; Gerald Salen; Ashok Kumir Batta; Adolfo Francesco Attili; Marco Badiali |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Obesity surgery Volume: 15 ISSN: 0960-8923 ISO Abbreviation: Obes Surg Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2005-04-13 Completed Date: 2005-07-14 Revised Date: 2007-12-05 |
Medline Journal Info:
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Nlm Unique ID: 9106714 Medline TA: Obes Surg Country: Canada |
Other Details:
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Languages: eng Pagination: 367-77 Citation Subset: IM |
Affiliation:
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Dipartimento di Medicina Clinica Divisione di Gastroenterologia, Italy. stefano.corradini@uniroma1.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Bile Acids and Salts / analysis Biliopancreatic Diversion / methods* Cholestanol / analysis Cholesterol / analysis, blood* Cholesterol, HDL / blood Cholesterol, LDL / blood Feces / chemistry Female Follow-Up Studies Gastric Bypass / methods* Humans Hypercholesterolemia / blood, therapy Jejunoileal Bypass / methods* Male Obesity, Morbid / blood, surgery* Phytosterols / analysis Prospective Studies Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Bile Acids and Salts; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Phytosterols; 0/Triglycerides; 57-88-5/Cholesterol; 80-97-7/Cholestanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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