Document Detail

Comparison of cerebral blood flow and injury following intracerebral and subdural hematoma in the rat.
MedLine Citation:
PMID:  10350538     Owner:  NLM     Status:  MEDLINE    
Subdural hematomas (SDH) can induce ischemia and neuronal damage in the underlying cortex. However, the extent to which intracerebral hematomas (ICH) produce reductions in cerebral blood flow (CBF) sufficient to cause ischemic damage is uncertain. Intracranial hemorrhage was induced by the injection of 100 or 200 microl of blood into the subdural space (SDH) or into the caudate nucleus (ICH) of the rat. CBF was measured using [14C]-iodoantipyrine autoradiography at 4 h. Brain damage was measured using 2,3, 5-triphenyl tetrazolium chloride (TTC) staining at 24 h and brain edema was measured using the wet/dry weight method. Brain ion contents were measured at 24 h using a flame photometer and chloridometer. In the CBF studies, the volume of tissue perfused below the ischemic threshold (<20 ml/100 g/min) for SDH was 122+/-35 mm3 (sham: 3.3+/-1.7 mm3). Following ICH, there was a small volume of tissue perfused below the ischemic threshold 50+/-11 mm3 (sham: 3. 3+/-2.5 mm3) but this volume corresponded closely to the volume of clot (71+/-5 mm3). The extent of brain damage, measured by TTC staining, in the cerebral cortex correlated with the increasing volume of the subdural blood clot (sham: 9+/-3 mm3; 200 microl: 81+/-19 mm3; P<0.01). Conversely, minimal brain damage was detected following ICH. The injection of blood into the subdural space or into the brain parenchyma induced blood volume-dependent increases in brain water content at 24 h. Increases in brain water content after SDH, were confined to the cerebral cortex (sham: 0.1+/-0.1 g/g dry weight; 200 microl: 0.8+/-0.3 g/g dry weight; P<0.001). In contrast, increases in brain water content after ICH were predominantly in the subcortical region (sham: 0.1+/-0.1 g/g dry weight; 200 microl: 0.4+/-0.2 g/g dry weight; P<0.01). The present investigations demonstrate differences in CBF, brain injury and edema formation following SDH and ICH indicating that these conditions may require different therapeutic interventions.
T R Patel; G P Schielke; J T Hoff; R F Keep; A Lorris Betz
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  829     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-08-02     Completed Date:  1999-08-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  125-33     Citation Subset:  IM    
Copyright Information:
Copyright 1999 Elsevier Science B.V.
Department of Surgery (Neurosurgery), University of Michigan, Ann Arbor, MI, USA.
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MeSH Terms
Body Water / metabolism
Brain Edema / physiopathology
Cerebral Hemorrhage / physiopathology*
Cerebral Infarction / pathology,  physiopathology
Cerebrovascular Circulation / physiology*
Coloring Agents
Hematoma / physiopathology*
Hematoma, Subdural / physiopathology*
Rats, Sprague-Dawley
Tetrazolium Salts / pharmacology
Grant Support
Reg. No./Substance:
0/Coloring Agents; 0/Ions; 0/Tetrazolium Salts; 902-00-1/triphenyltetrazolium

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