| Comparison of cerebral blood flow in computed tomographic hypodense areas of the brain in head-injured patients. | |
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MedLine Citation:
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PMID: 12535362 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Hypodense lesions identified on computed tomographic (CT) scans are often assumed to indicate ischemia. The purpose of this study was to investigate regional cerebral blood flow (rCBF) in hypodense areas of the brain after severe traumatic brain injury. METHODS: CBF was measured by stable xenon-enhanced CT scans. Hypodense areas were identified, and rCBF values as well as CT density were averaged for the region. RESULTS: Thirty (60%) of the 50 patients had a total of 45 hypodense regions, which were associated with either contusion (n = 30) or areas of infarction (n = 15). rCBF in the hypodense regions was variable, ranging from a low of 3.3 to a high of 72.5 ml/100 g/min. The cause of the lesion was the major factor associated with the level of rCBF. Although the average decrease in CT density was similar for the two types of lesions, the average rCBF was significantly lower and the difference in rCBF between the lesion and the contralateral side was greater when the hypodense lesion was associated with a contusion. A critical reduction in rCBF (<20 ml/100 g/min) was found in 19 (63%) of the hypodense regions associated with contusions but in only 4 (27%) of those from areas of infarction. CONCLUSION: Hypodensity on plain CT scans does not always indicate reduction in CBF. This association was found more commonly when the low-density area was associated with a contusion. In hypodense areas associated with infarction, rCBF was variable and not commonly in the ischemic range at the time the CBF measurement was obtained. |
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Authors:
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Yu Furuya; Roman Hlatky; Alex B Valadka; Pedro Diaz; Claudia S Robertson |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Neurosurgery Volume: 52 ISSN: 0148-396X ISO Abbreviation: Neurosurgery Publication Date: 2003 Feb |
Date Detail:
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Created Date: 2003-01-21 Completed Date: 2003-03-24 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7802914 Medline TA: Neurosurgery Country: United States |
Other Details:
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Languages: eng Pagination: 340-5; discussion 345-6 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, St. Marianna University School of Medicine, Kawasaki, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Flow Velocity / physiology Brain / blood supply* Brain Concussion / radiography*, surgery Cerebral Infarction / radiography*, surgery Dominance, Cerebral / physiology Female Glasgow Coma Scale Head Injuries, Closed / radiography*, surgery Hematoma, Epidural, Cranial / radiography, surgery Hematoma, Subdural, Acute / radiography, surgery Humans Male Middle Aged Regional Blood Flow / physiology Sensitivity and Specificity Xenon / diagnostic use |
| Grant Support | |
ID/Acronym/Agency:
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P01-NS38660/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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7440-63-3/Xenon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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