Document Detail

Comparison of central blood pressure and cardio-ankle vascular index for association with cardiac function in treated hypertensive patients.
MedLine Citation:
PMID:  19779490     Owner:  NLM     Status:  MEDLINE    
Recent automated applanation tonometry can measure radial pulse wave-derived central blood pressure (CBP), which has shown a prognostic value independently of peripheral blood pressure. However, CBP's clinical significance has not been fully established. We examined the associations between CBP and cardiac structure and function by comparing them with those of arterial stiffness assessed by cardio-ankle vascular index (CAVI) in treated hypertensive patients. Enrolled in the study were 102 patients (71+/-7 years) with treated hypertension. The transmitral early-to-atrial velocity ratio (E/A), peak systolic (S'), early diastolic (E') mitral annular velocities and the Tei index were measured as indexes of cardiac function derived from conventional and tissue Doppler echocardiography. Left ventricular mass index (LVMI) was measured as an index of LV hypertrophy. CBP and CAVI were measured just after echocardiographic examination. CBP, but not CAVI, correlated with LVMI (r=0.306, P<0.01). Although CBP correlated only with the Tei index (r=0.201, P<0.05), CAVI correlated with E/A (r=-0.387, P<0.001), S' (r=-0.270, P<0.01), E' (r=-0.362, P<0.01) and the Tei index (r=0.339, P<0.01). Stepwise regression analysis revealed that neither CBP nor CAVI was independently associated with E/A, S' or E'. However, CAVI, but not CBP, was independently associated with the Tei index (beta coefficient=0.311, P<0.001), reflecting both LV systolic and diastolic function. In conclusion, CBP may be suitable for detecting LV hypertrophy. In contrast, CAVI may be suitable for detecting LV dysfunction. This difference, suggesting the clinical value of each parameter, should be kept in mind when we use CBP and CAVI for assessing arteriosclerosis in treated hypertension.
Hisashi Masugata; Shoichi Senda; Hiroyuki Okuyama; Koji Murao; Michio Inukai; Naohisa Hosomi; Kazushi Yukiiri; Akira Nishiyama; Masakazu Kohno; Fuminori Goda
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2009-09-25
Journal Detail:
Title:  Hypertension research : official journal of the Japanese Society of Hypertension     Volume:  32     ISSN:  1348-4214     ISO Abbreviation:  Hypertens. Res.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-03     Completed Date:  2010-02-24     Revised Date:  2010-04-06    
Medline Journal Info:
Nlm Unique ID:  9307690     Medline TA:  Hypertens Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1136-42     Citation Subset:  IM    
Department of Integrated Medicine, Kagawa University, Kita-gun, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Ankle Brachial Index*
Arteriosclerosis / physiopathology,  ultrasonography
Blood Flow Velocity
Blood Pressure Determination / methods*
Hypertension / diagnosis*,  physiopathology*
Hypertrophy, Left Ventricular / physiopathology*,  ultrasonography*
Middle Aged
Predictive Value of Tests
Pulsatile Flow
Regression Analysis
Comment In:
Hypertens Res. 2010 Apr;33(4):380   [PMID:  20139922 ]
Hypertens Res. 2009 Dec;32(12):1056-8   [PMID:  19851327 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Prenatal dehydration alters renin-angiotensin system associated with angiotensin-increased blood pre...
Next Document:  Evaluation of arterial stiffness in morning hypertension under high-dose valsartan compared to valsa...